Transparent Labs - Vitality - 60 Capsules

Transparent Labs Vitality is a 3-in-1 natural testosterone optimization formula built around three simultaneous hormonal objectives: supporting testosterone production through the hypothalamic-pituitary-gonadal (HPG) axis, managing the hormonal ratio side by controlling aromatase-driven estrogen conversion, and reducing cortisol's suppressive effect on testosterone through adaptogenic stress modulation. Eight ingredients — all premium branded or patented forms — covering the full hormonal environment a man needs to maintain optimal testosterone function as he ages, trains hard, and deals with the chronic stress that suppresses the HPG axis. 60 capsules, 30 servings. Third-party tested. California Prop 65 Warning applies.†

Supplement Facts — Transparent Labs Vitality (Per 2 Capsule Serving)

• Zinc (as L-OptiZinc, Zinc L-Methionine) — 15mg
• KSM-66 Organic Ashwagandha Root Extract — 600mg
• PrimaVie Shilajit Extract — 250mg
• Quercetin Dihydrate — 250mg
• DIM (Diindolylmethane) — 125mg
• LJ100 Eurycoma longifolia (Tongkat Ali) Root Extract — 100mg — standardized to 22% Bioactive Eurypeptides, 40% Glyco Saponins
• BioPerine (Black Pepper Fruit Extract) — 10mg
• Boron (as Bororganic Glycine) — 5mg
• Other Ingredients: Hypromellose (HPMC) capsule, L-Leucine
• No artificial anything. Fully transparent label. Third-party tested.
• 60 capsules. 30 servings. Take 2 capsules daily with food.
• California Prop 65 Warning applies — see label

What's Inside Transparent Labs Vitality — Three Hormonal Mechanisms, Eight Ingredients

The Testosterone Problem No One Talks About Honestly

Testosterone levels in men have declined significantly in the modern era — research comparing age-matched men across decades consistently shows that men today have substantially lower testosterone than men of the same age in previous generations, independent of body weight or lifestyle factors. The causes are multifactorial: chronic stress elevating cortisol (which directly suppresses testosterone production by inhibiting the HPG axis), environmental xenoestrogen exposure disrupting hormonal signaling, sedentary lifestyle reducing the anabolic stimulus that drives testosterone production, nutritional deficiencies in minerals like zinc and boron that serve as cofactors in testosterone biosynthesis, and the natural age-related decline in Leydig cell function beginning in the mid-30s.†

Vitality addresses this environment with a formula designed around three distinct mechanisms of action — not just "take an herb and hope testosterone goes up," but a considered hormonal strategy that simultaneously supports the upstream signals that stimulate testosterone production, protects the testicular tissue that produces it, manages the downstream conversion that reduces it, and addresses the cortisol elevation that suppresses it.†

Mechanism 1 — HPG Axis Stimulation: LH/FSH and Testosterone Production Support

• LJ100 Eurycoma longifolia (Tongkat Ali) Root Extract — 100mg

  LJ100 is the most clinically researched Tongkat Ali extract available — a patented, standardized extract from MIT-Biomed, standardized to 22% bioactive eurypeptides and 40% glyco saponins. These two standardizations are what separate LJ100 from the generic Tongkat Ali extracts that dominate the market at comparable price points, because the eurypeptides are the specific class of compounds responsible for Tongkat Ali's clinically documented testosterone-supporting effects.†

  Tongkat Ali's mechanism operates through two pathways simultaneously. First, it stimulates the production and release of luteinizing hormone (LH) from the pituitary gland. LH is the hormonal signal that travels to the Leydig cells in the testes and stimulates them to produce testosterone — it is the direct upstream command signal for testicular testosterone synthesis. By amplifying LH output, Tongkat Ali supports the body's own endogenous testosterone production through the natural pathway rather than bypassing it. Second, LJ100's quassinoids — specifically eurycomanone — have been shown to support free testosterone by inhibiting sex hormone-binding globulin (SHBG), the protein that binds to testosterone and renders it biologically inactive. Lower SHBG means more of the testosterone produced is in the biologically active free fraction.†

  Multiple human clinical trials on LJ100 specifically (not generic Tongkat Ali) have documented significant improvements in the testosterone-to-cortisol ratio, increases in lean body mass, improvements in strength, and improvements in libido and sexual function in both healthy men and men with suboptimal testosterone levels. At 100mg of LJ100 per serving, Vitality provides the dose that appears in the primary published clinical literature.†

• PrimaVie Shilajit Extract — 250mg

  PrimaVie is the premium, purified, and standardized shilajit extract from Natreon Inc. — the only shilajit with published human clinical trial data specifically in the context of testosterone support. Shilajit is a naturally occurring exudate found on the rocks of the Himalayan mountains, formed over millennia from the decomposition of organic plant material, and has been used in Ayurvedic medicine as a rejuvenating agent for over 3,000 years.†

  Shilajit's primary bioactive compounds are fulvic acid and a specific class of compounds called dibenzo-alpha-pyrones (DBPs). These compounds support mitochondrial function, cellular energy production, and — relevant to Vitality — the activity of the enzymes involved in steroidogenesis (the production of steroid hormones including testosterone). Research on PrimaVie specifically has documented statistically significant increases in total testosterone, free testosterone, and DHEA levels in healthy men over 90 days of supplementation compared to placebo. The PrimaVie standardization ensures the fulvic acid content and DBP content are consistent across batches — a quality differentiation that matters given the wide variability in raw shilajit quality and the significant risk of heavy metal contamination in non-purified shilajit sources.†

• Zinc (as L-OptiZinc, Zinc L-Methionine) — 15mg

  L-OptiZinc is a patented zinc-methionine complex from InterHealth Nutraceuticals, consistently shown to be among the most bioavailable forms of zinc supplementation. Zinc is a non-negotiable mineral cofactor in the testosterone production pathway — it serves as a direct cofactor for multiple enzymes in the steroidogenesis cascade, including 17β-hydroxysteroid dehydrogenase, which catalyzes the final conversion step in testosterone biosynthesis. Zinc deficiency directly impairs testosterone production at the cellular level, and athletes who sweat heavily are among the most vulnerable populations for zinc depletion, losing meaningful amounts of zinc through sweat at rates that dietary intake frequently cannot compensate for.†

  Beyond testosterone production, zinc plays a critical role in pituitary LH secretion — the upstream signal that triggers testicular testosterone synthesis — making it relevant to the HPG axis at multiple levels. Zinc also inhibits aromatase activity, providing some degree of estrogen management support that complements the DIM and Quercetin in the formula.†

• Boron (as Bororganic Glycine) — 5mg

  Bororganic Glycine is an organic, highly bioavailable form of boron — a trace mineral that has emerged in research as one of the most impactful overlooked testosterone-supporting micronutrients. Human clinical research on boron supplementation at 6mg daily for 7-60 days has documented significant increases in free testosterone, decreases in estradiol, and reductions in SHBG — producing meaningful improvements in the free testosterone ratio. Boron works in part by reducing SHBG (increasing free testosterone availability) and in part by supporting the activity of steroidogenic enzymes. It is also a cofactor in the utilization of vitamin D, which is itself critical for testosterone production.†

Mechanism 2 — Aromatase and Estrogen Management

• DIM (Diindolylmethane) — 125mg

  DIM is a compound derived from indole-3-carbinol, which is produced when the body metabolizes cruciferous vegetables — broccoli, Brussels sprouts, cauliflower, and cabbage. DIM is a potent modulator of estrogen metabolism that works by promoting the conversion of stronger, less favorable estrogen metabolites (specifically 16α-hydroxyestrone, associated with fat gain and hormonal imbalance) toward weaker, more favorable estrogen metabolites (specifically 2-hydroxyestrone, with anti-estrogenic properties). This estrogen pathway modulation reduces the net estrogenic activity in the body without completely eliminating estrogen — which is important because estrogen is not entirely unwanted in men (it plays a role in bone health, libido, and cardiovascular health) and complete estrogen suppression creates its own set of problems.†

  DIM also has mild aromatase-inhibiting properties, reducing the activity of the enzyme that converts testosterone to estradiol. For men with higher body fat percentages — where adipose tissue contains concentrated aromatase activity — DIM provides meaningful support in improving the testosterone-to-estradiol ratio. At 125mg, Vitality provides a functional dose of DIM consistent with the levels used in research documenting estrogen metabolite ratio improvements.†

• Quercetin Dihydrate — 250mg

  Quercetin is a polyphenol flavonoid with documented aromatase-inhibiting activity alongside its well-known antioxidant and cardiovascular-protective properties. Its most relevant role in Vitality is testicular tissue protection — quercetin has been shown in multiple preliminary studies to protect Leydig cells, the testosterone-producing cells within the testes, from oxidative stress and toxin-induced damage. Chronic oxidative stress at the testicular level is one of the mechanisms by which environmental toxins, heavy exercise, and aging reduce testosterone output independently of hormonal signaling. By providing antioxidant protection specifically relevant to Leydig cell function, quercetin addresses the cellular health dimension of testosterone production that hormonal signaling ingredients alone cannot reach.†

  Quercetin's anti-estrogenic properties come from its ability to inhibit aromatase activity, complementing DIM's estrogen metabolite modulation. The combination of DIM and Quercetin in the same formula provides estrogen management from two distinct angles — metabolite pathway optimization (DIM) and enzyme activity inhibition (Quercetin) — for more complete estrogen management support than either ingredient provides alone.†

Mechanism 3 — Cortisol Management and Testosterone-to-Cortisol Ratio

• KSM-66 Organic Ashwagandha Root Extract — 600mg

  KSM-66 is the most extensively studied ashwagandha extract in the world — 24+ published human clinical trials covering stress reduction, cortisol management, cognitive performance, athletic recovery, and testosterone support. It is root-only extracted organic ashwagandha standardized to minimum 5% withanolides, the primary bioactive compounds. The full KSM-66 profile is covered in detail in the Transparent Labs KSM-66 Ashwagandha standalone product — in the context of Vitality, its most critical role is cortisol management and the resulting improvement in the testosterone-to-cortisol ratio.†

  Cortisol is testosterone's direct biochemical antagonist. Both cortisol and testosterone are synthesized from the same pregnenolone precursor — when chronic stress drives up cortisol demand, the shared biosynthetic pathway diverts pregnenolone toward cortisol production and away from testosterone. This "pregnenolone steal" is a primary mechanism by which chronic training stress, life stress, poor sleep, and caloric restriction all suppress testosterone. KSM-66's documented ability to reduce serum cortisol by approximately 28% in chronically stressed individuals directly addresses this pregnenolone competition, freeing the pathway for testosterone synthesis. Clinical research on KSM-66 in resistance-trained men has specifically documented significant improvements in testosterone levels alongside the cortisol reduction — validating the mechanism in the athletic population most relevant to Vitality's target users.†

• BioPerine (Black Pepper Fruit Extract, 95% Piperine) — 10mg

  BioPerine is the patented piperine absorption enhancer from Sabinsa Corporation. Piperine inhibits the metabolic enzymes (CYP3A4 and P-glycoprotein) responsible for breaking down active compounds in the liver and intestinal wall during the first-pass metabolism. The result is meaningfully higher bioavailability and systemic exposure to the other active ingredients in the formula. At 10mg, Vitality provides a generous dose of BioPerine — double the 5mg that many formulas include. This absorption enhancement is particularly important for ingredients like KSM-66, DIM, Quercetin, and shilajit compounds that are variably bioavailable without absorption support.†

Frequently Asked Questions About Transparent Labs Vitality

1. How does Vitality compare to other testosterone boosters on the market?
   The primary differentiator is the use of exclusively premium, patented, clinically-researched ingredient forms — LJ100 (not generic Tongkat Ali), PrimaVie (not generic shilajit), KSM-66 (not generic ashwagandha), L-OptiZinc (not zinc oxide), Bororganic Glycine (not generic boron), BioPerine (not generic black pepper) — combined with full label transparency disclosing every dose. The majority of testosterone boosters on the market either use generic, unstandardized forms of these ingredients at doses too low to replicate the research, or hide their doses in proprietary blends so you cannot verify what you are actually taking. Vitality provides the research-grade forms at disclosed, research-calibrated doses. The formula is also notably focused on the full hormonal picture — it addresses testosterone production, estrogen management, and cortisol suppression simultaneously rather than stacking ten herbs at cosmetic doses and calling it comprehensive.†
2. Who should take Vitality and at what age does it become most relevant?
   Vitality is designed for adult men and becomes most impactful for men over 30 — when the natural decline in Leydig cell function begins producing measurable year-over-year reductions in testosterone, and when the cumulative effects of chronic stress, heavy training history, and potential nutritional gaps in zinc and boron start to compound. That said, younger men who train intensely, are in a caloric deficit, have high chronic stress, or have been tested and found to have below-optimal testosterone levels for their age can also benefit meaningfully. The cortisol management through KSM-66 alone makes Vitality relevant for any athlete pushing volume who notices reduced libido, energy, mood, or training performance — classic signs of training-induced testosterone suppression from elevated cortisol.†
3. How long does it take to see results?
   The timeline varies by ingredient and mechanism. Tongkat Ali's effects on the testosterone-to-cortisol ratio are documented in research at 4-12 weeks of daily use. KSM-66's cortisol reduction builds over 4-8 weeks. PrimaVie shilajit's testosterone support in published research was documented at 90 days. The mineral support from zinc and boron works most rapidly — within 1-4 weeks — particularly for men who were deficient. Most users report subjective improvements in energy, libido, and mood within 2-4 weeks, with more significant body composition and performance-related changes requiring 8-12 weeks of consistent daily use.†
4. Can Vitality be stacked with Transparent Labs ZMO or other products?
   Vitality and ZMO share Zinc and have some overlap in intent (both support male hormonal health), so the primary consideration when stacking them is cumulative zinc intake — together they would provide a meaningful zinc dose. This is generally not a concern for most men, particularly athletes, but those monitoring mineral intake should be aware. Vitality stacks particularly well with Transparent Labs Creatine HMB — creatine supports the training output that drives anabolic adaptation, while Vitality supports the hormonal environment that determines the magnitude of those adaptations. KSM-66 in Vitality also makes a standalone KSM-66 purchase redundant if you are already taking Vitality at the full 2-capsule dose.†

How to Take Transparent Labs Vitality

Take 2 capsules (1 serving) once daily with food, ideally earlier in the day. Consistent daily use is essential — the hormonal mechanisms in Vitality require cumulative daily exposure to produce and maintain meaningful effects. Do not skip days. For optimal results, use consistently for a minimum of 8-12 weeks while maintaining a resistance training program, adequate sleep (7-9 hours), and sufficient caloric intake. Use only as directed. Do not exceed the recommended serving. If using other hormonal supplements, consult a physician before combining. California Residents: Prop 65 Warning applies — see label.†

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Who Should Not Take Transparent Labs Vitality

• Not for use by persons under 18
• Not for women — Vitality is specifically formulated for male hormonal optimization
• Not for pregnant or nursing women
• Consult a physician before use if you have any hormone-sensitive condition, including prostate concerns — testosterone optimization supplements are contraindicated in some prostate health contexts
• Consult a physician before use if you are currently on hormone replacement therapy (TRT) or any other hormonal medication — the ingredients in Vitality interact with the endocrine system and may alter medication requirements
• Consult a physician before use if taking blood thinners or medications metabolized by CYP3A4 — BioPerine's piperine inhibits CYP3A4 and may alter drug metabolism and clearance rates
• Consult a physician before use if you have kidney or liver disease
• Discontinue use and consult a physician if you experience any adverse reactions
• California Residents: This product can expose you to chemicals including Lead, known to the State of California to cause cancer and birth defects or other reproductive harm. Visit www.P65Warnings.ca.gov/food for more information
• Keep out of reach of children

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.