Hi-Tech Pharmaceuticals - Arimistane - 60 Tablets

Hi-Tech Pharmaceuticals Arimistane® delivers 50mg of Androsta-3,5-diene-7,17-dione per tablet — a naturally occurring downstream metabolite of DHEA that is the most potent legal suicide aromatase inhibitor available as a dietary supplement — using Cyclosome® Technology (HPBCD + Phosphatidylcholine 75%) for enhanced bioavailability through the lymphatic absorption pathway. Hi-Tech holds the registered trademark on the Arimistane® name and has developed a proprietary purification process that achieves 98.5% purity — in contrast to generic Androsta-3,5-diene-7,17-dione products that Hi-Tech's own testing has found to contain as little as 60% of the stated compound, with unknown impurities comprising the remaining 40%. As a suicide aromatase inhibitor, Arimistane® permanently and irreversibly binds to the aromatase enzyme — preventing estrogen rebound after the compound clears, unlike non-suicidal AIs. Take 1 tablet in the morning and 1 tablet in the evening. Do not exceed 2 tablets daily. 60 tablets — 30-day supply. Not for women. Not for persons under 18. California Prop 65 Warning applies.†

Supplement Facts — Hi-Tech Pharmaceuticals Arimistane® (Per 1 Tablet / 60 Servings)

• Androsta-3,5-diene-7,17-dione (as Arimistane®) — 50mg

• Other Ingredients: Microcrystalline Cellulose, Phosphatidylcholine 75%, Hydroxypropyl Beta Cyclodextrin (HPBCD), Phytosterols, Magnesium Stearate, Silica, FD&C Blue #2, FD&C Red #40

• Delivery: Cyclosome® Technology (HPBCD + Phosphatidylcholine 75%) — lymphatic absorption, bypasses hepatic first-pass

• Purity: 98.5% — Hi-Tech trademark holder, proprietary purification process

• Suicide aromatase inhibitor — permanently binds aromatase, no estrogen rebound

• Take 1 tablet in the morning and 1 tablet in the evening

• Do not exceed 2 tablets daily

• 60 tablets — 30-day supply at twice-daily dosing

• Uses: on-cycle estrogen management, standalone estrogen blocker and test support, cutting phase hormonal optimization

• Not a standalone PCT replacement — use Arimiplex for full PCT post-prohormone cycle

• Not for women. Not for persons under 18.

• Discontinue immediately if rapid heartbeat, dizziness, or vomiting occurs

• Consult a physician before use if taking any prescription medications or having any medical condition

• California Prop 65 Warning applies.

What Arimistane® Is — The Suicide AI Explained

Androsta-3,5-diene-7,17-dione (Arimistane®) is a metabolite of 7-Keto DHEA — a naturally occurring compound in the human body that is produced as a downstream metabolite of the DHEA cascade. It does not convert into testosterone or estrogen itself. Its biological activity is specifically as an aromatase inhibitor: it binds to the aromatase enzyme (CYP19A1) — the enzyme responsible for converting testosterone and androstenedione into estrogens (estradiol, estrone) — and reduces estrogen production from the downstream testosterone conversion pathway.†

The "suicide" or "steroidal" designation is what makes Arimistane® categorically different from non-steroidal aromatase inhibitors like pharmaceutical anastrozole or letrozole, and from the OTC product DIM. Suicide aromatase inhibitors bind to the aromatase enzyme irreversibly — just like the pharmaceutical exemestane (Aromasin®), which Arimistane® most closely resembles in mechanism. When a molecule of Arimistane® binds to aromatase, that enzyme molecule is permanently deactivated — it cannot be unbound and reactivated. New estrogen production at that enzyme site only resumes when the body synthesizes new aromatase enzyme. This irreversible binding mechanism is specifically what prevents estrogen rebound — the phenomenon where stopping a non-steroidal AI causes a rapid spike in estrogen as previously inhibited enzyme resumes full activity. Suicide AIs don't rebound because the enzyme has been permanently deactivated, not temporarily suppressed.†

The Four Documented Hormonal Effects

1 — Aromatase Inhibition and Estrogen Reduction

The primary and most potent effect of Arimistane® is direct inhibition of the aromatase enzyme, reducing the conversion of testosterone to estrogen. For men running prohormone cycles where conversion to estrogen is a concern (particularly with 4-Andro and testosterone-pathway compounds), or for men who experience estrogen-related symptoms (bloating, water retention, nipple sensitivity, mood changes) naturally or in response to training and diet changes, Arimistane® directly addresses the enzymatic source of excess estrogen production. The first effects users notice is a drying out and hardening effect — the reduction of subcutaneous water retention that excess estrogen drives — producing increased vascularity and muscle definition within the first 1-2 weeks of use.†

2 — LH Elevation and Testosterone Support

Estrogen levels in men are a key feedback signal in the hypothalamic-pituitary-gonadal (HPG) axis — when estrogen is high, it signals the hypothalamus to reduce GnRH secretion and the pituitary to reduce LH output, which suppresses testicular testosterone production. By reducing circulating estrogen, Arimistane® removes this inhibitory feedback, allowing LH levels to rise and testicular testosterone synthesis to increase. Research has documented that Arimistane® raises LH (luteinizing hormone) and increases testosterone levels — both through the direct estrogen reduction mechanism and potentially through direct pituitary effects. This makes Arimistane® simultaneously an estrogen blocker and a natural testosterone support compound.†

3 — Cortisol Reduction

Beyond the estrogen-testosterone hormonal axis, Arimistane® has documented effects on cortisol — the primary catabolic stress hormone that elevates in response to intense training, caloric deficit, and chronic stress. Elevated cortisol promotes muscle protein breakdown, fat accumulation (particularly visceral), and suppresses the anabolic hormone environment. Arimistane® helps reduce cortisol levels, contributing to the anti-catabolic environment that supports muscle retention during cutting phases and enhanced recovery between training sessions. This cortisol-reducing effect adds a meaningful dimension to Arimistane®'s usefulness during calorie-restricted phases specifically.†

4 — DHT Management

Arimistane® has been noted for its role in helping reduce DHT — particularly relevant for prohormone cycle users who are concerned about androgenic side effects including hair loss and prostate stress. By modulating the androgenic environment alongside estrogen management, Arimistane® provides more complete hormonal management than a pure aromatase inhibitor.†

Purity — Why Hi-Tech's 98.5% Matters

The supplement industry for Androsta-3,5-diene-7,17-dione has a significant purity problem that Hi-Tech Pharmaceuticals has documented directly. Hi-Tech has tested competing products and found that many generic Androsta-3,5-diene-7,17-dione supplements test at approximately 60% purity — meaning that only 60% of the stated compound is actually the intended active, with the remaining 40% consisting of unknown impurities from inferior synthesis processes. The implications are twofold: users are getting significantly less active Arimistane® than the label states, and the unknown 40% may include synthesis byproducts with unpredictable or adverse biological activity.†

Hi-Tech's 98.5% purity figure reflects a proprietary purification process the company has developed specifically for Arimistane® production — a process they own and have invested significantly in. Hi-Tech holds the registered trademark on the Arimistane® name, and while they license this mark to other companies, the underlying synthesis and purification quality varies significantly between licensees and generic producers. When buying Hi-Tech Pharmaceuticals Arimistane® specifically, the 98.5% purity guarantee is from the compound's trademark holder, not a third-party using the name.†

Cyclosome® Technology — Why It Matters for Arimistane®

Androsta-3,5-diene-7,17-dione, like other steroidal compounds, faces significant first-pass hepatic metabolism that limits the fraction of an oral dose reaching systemic circulation intact. Hi-Tech is also the only company selling a Cyclosomal version of Arimistane® — a distinction that matters for bioavailability. The Cyclosome® HPBCD cyclodextrin complexation encapsulates the compound and protects it from first-pass enzymatic degradation. The Phosphatidylcholine 75% liposomal encapsulation facilitates absorption through the intestinal lymphatic system (lacteals) rather than the portal blood system, bypassing the liver's first-pass metabolism entirely. The result is more intact Arimistane® reaching systemic circulation per 50mg tablet than unformulated or conventionally formulated Androsta-3,5-diene-7,17-dione tablets deliver.†

Three Use Contexts — On-Cycle, Post-Cycle, and Standalone

On-Cycle Estrogen Management

Arimistane® is specifically recommended for on-cycle use with prohormone compounds that aromatize to estrogen — particularly 4-Andro (Androdiol) and any testosterone-pathway prohormone. Taking 1 tablet morning and 1 tablet evening throughout the entire prohormone cycle prevents the estrogen elevation that can cause water retention, gynecomastia (nipple sensitivity and breast tissue growth), and the HPG axis suppression from excess estrogen that counteracts the cycle's testosterone-building intent. Arimistane® used on-cycle replaces the need for pharmaceutical anastrozole or letrozole for estrogen management — it provides suicide AI protection at a fraction of the cost and without prescription requirement.†

Post-Cycle Use — As Part of a PCT Stack

Post-cycle, Arimistane® addresses the estrogen rebound dimension of PCT. After a prohormone cycle ends and exogenous hormones clear, estrogen rebound is a significant concern — residual aromatase activity can convert the remaining elevated androgens to estrogen faster than natural testosterone production recovers, creating a temporary state of high estrogen and low testosterone that produces fatigue, mood changes, and muscle loss. Arimistane®'s suicide binding mechanism specifically prevents this rebound by permanently deactivating aromatase enzyme molecules — new enzyme must be synthesized before full aromatase activity recovers, buying time for natural testosterone production to re-establish. However, Arimistane® alone is not sufficient PCT for a prohormone cycle — it must be combined with Arimiplex (which contains Clomiphene-analog botanical compounds and natural testosterone boosters) for complete HPG axis recovery.†

Standalone Use — Natural Hormonal Optimization

Arimistane® can be used as a standalone supplement without any prohormone history — for men who want to manage naturally elevated estrogen, reduce water retention, improve muscle hardness and vascularity, and support natural testosterone levels through estrogen reduction. In this context, Arimistane® functions as a natural estrogen management tool appropriate for the cutting phase, when estrogen-related water retention blurs definition, or for men in age-related estrogen-to-testosterone ratio decline who want botanical estrogen management support.†

Arimistane® vs. Arimiplex — The Critical Distinction

Customers frequently confuse Arimistane® and Arimiplex, and the distinction is important for appropriate use. Arimistane® is a single-ingredient suicide aromatase inhibitor — it reduces estrogen production and supports testosterone through estrogen removal. It does not contain LH-stimulating compounds, SERM-like botanical compounds, liver support, or the comprehensive PCT support matrix that full recovery from a suppressive prohormone cycle requires. Arimiplex is Hi-Tech's complete PCT formula — it contains multiple testosterone-boosting botanical compounds, LH stimulants, liver support ingredients, and comprehensive post-cycle hormonal recovery support alongside aromatase inhibitor coverage.†

The correct protocol: use Arimistane® on-cycle for estrogen management while running a prohormone. At end of cycle, transition to Arimiplex for full PCT. Some users run Arimistane® additionally alongside Arimiplex during PCT for enhanced estrogen control during the recovery period — this is the most comprehensive approach. Arimistane® alone as PCT for a suppressive prohormone cycle is not recommended.†

Frequently Asked Questions

1. What is a "suicide aromatase inhibitor" and why does it matter?
   A suicide AI (also called a steroidal AI) permanently and irreversibly binds to the aromatase enzyme, deactivating each enzyme molecule it contacts. Non-steroidal AIs (like anastrozole and letrozole, and most OTC estrogen blockers) bind reversibly — when you stop taking them, the enzyme resumes full activity, often causing an estrogen rebound spike. Suicide AIs like Arimistane® (similar to pharmaceutical Aromasin/exemestane) prevent rebound because the deactivated enzyme molecules cannot reactivate — new aromatase must be synthesized before activity resumes, allowing testosterone to naturally re-establish without estrogen spiking during the recovery period.†

2. Can Arimistane® be used by itself or does it require a prohormone cycle?
   Arimistane® can be used as a standalone supplement without any prohormone cycle for natural estrogen management, muscle hardening, water retention reduction, and natural testosterone support through estrogen removal. It is commonly used by men who want lean body composition support and hormonal optimization without running a prohormone cycle. Take 1 tablet morning and 1 tablet evening for the standalone application.†

3. Does Arimistane® need to be cycled?
   For on-cycle prohormone use: take throughout the entire prohormone cycle and transition to Arimiplex for PCT at cycle's end. For standalone use: a typical protocol is 4-8 weeks of use followed by 4 weeks off before resuming, to prevent complete estrogen suppression that can cause joint discomfort, libido issues, and bone density concerns from estrogen levels being driven too low. Some estrogen is required for male physiology — the goal is optimization, not elimination.†

4. Will Arimistane® cause a positive drug test?
   Arimistane® (Androsta-3,5-diene-7,17-dione) is a DHEA metabolite and is prohibited by WADA and NCAA as an androgen metabolite. Athletes in any tested sport must not use Arimistane®. It is a legal dietary supplement for general use but is not appropriate for tested athletic contexts.†

How to Take Hi-Tech Pharmaceuticals Arimistane®

Take 1 tablet in the morning and 1 tablet in the evening. Can be taken with or without food. Do not exceed 2 tablets per day. For on-cycle prohormone use: take throughout the entire cycle alongside on-cycle liver support (Liver Rx or Gear Support). For post-cycle use: run alongside Arimiplex for complete PCT. For standalone use: run 4-8 week cycles with 4-week breaks to prevent excess estrogen suppression. Not for women. Not for persons under 18. Not for tested athletes — Arimistane® is prohibited by WADA and NCAA. Discontinue immediately if rapid heartbeat, dizziness, or vomiting occurs. Consult a physician before use if you have any medical conditions or are taking any prescription medications. California Prop 65 Warning applies.†

Why Buy at Get Yok'd

• Real-time inventory across all five Southern California stores

• Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood

• Authorized Hi-Tech Pharmaceuticals retailer — carrying Arimistane® alongside Arimiplex, the full Hi-Tech prohormone lineup, and all on-cycle and PCT support products

• Staff who can walk you through on-cycle, PCT, and standalone Arimistane® protocols and help you build the right complete cycle support stack in person

• One of the best loyalty programs in the supplement industry — earn rewards on every purchase

Who Should Not Take Arimistane®

• Not for women — women require estrogen for bone density, cardiovascular health, and normal physiological function; aromatase inhibition in women is only appropriate under physician supervision for specific medical conditions

• Not for persons under 18 years of age

• Not for tested athletes — Androsta-3,5-diene-7,17-dione is prohibited by WADA and NCAA as an androgen metabolite; will cause a positive drug test

• Not for men with bone density concerns without physician clearance — estrogen plays a role in male bone metabolism; excessive suppression can reduce bone mineral density

• Not for men with cardiovascular conditions without physician clearance

• Individuals who have experienced joint pain, low libido, or extreme fatigue from prior AI use should monitor for over-suppression of estrogen — both extremes of estrogen are problematic in male physiology

• Discontinue immediately if rapid heartbeat, dizziness, or vomiting occurs

• Consult a physician before use if taking any prescription medications or having any medical condition

• California Prop 65 Warning applies.

• Keep out of reach of children.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.