Hi-Tech Pharmaceuticals TUDCA delivers 250mg of Tauroursodeoxycholic Acid per capsule — a naturally occurring bile acid derivative with thousands of years of documented medicinal use and one of the most compelling hepatoprotective compounds in the modern supplement literature. TUDCA is the taurine conjugate of Ursodeoxycholic Acid (UDCA), a secondary bile acid synthesized in the gut from primary bile acids through bacterial biotransformation. 60 capsules per container — 60 servings at one capsule, or a 30-day supply at the recommended twice-daily dose. Take 1 capsule twice daily with 8-12oz of water. GMP Certified Facility. Hi-Potency — 250mg per serving. Supports liver and digestive health, immune and heart function, kidney and gallbladder health, gut health, energy levels, and memory and brain function. California Prop 65 Warning applies.†
Supplement Facts — Hi-Tech Pharmaceuticals TUDCA (Per 1 Veggie Capsule / 60 Servings)
TUDCA (Tauroursodeoxycholic Acid) — 250mg
Other Ingredients: Gelatin Capsule, Dicalcium Phosphate, Sodium Starch Glycolate (Explotab®), Magnesium Stearate (vegetable source), Silica
Explotab® (Sodium Starch Glycolate) — fast-dissolving disintegrant for rapid capsule dissolution and compound release
60 capsules per container — 60 single-capsule servings, or 30-day supply at 2 capsules daily
Take 1 capsule twice daily with 8-12oz of water, or as directed by your healthcare professional
GMP Certified Facility. Sourced from GMP Certified Facility.
Not for pregnant or nursing women without physician clearance
Consult a physician before use if taking prescription medications
California Prop 65 Warning applies.
What TUDCA Is — A Bile Acid With Extraordinary Range
Tauroursodeoxycholic Acid (TUDCA) is the taurine-conjugated form of Ursodeoxycholic Acid — a water-soluble secondary bile acid found in small amounts in human bile and in significantly higher concentrations in bear bile, where it has been used in traditional Asian medicine for thousands of years. The pharmaceutical version of the non-taurine conjugate (UDCA, brand name Actigall/Ursodiol) is an FDA-approved prescription medication for primary biliary cholangitis and gallstone dissolution. TUDCA, as a dietary supplement, is the more bioavailable taurine conjugate — the addition of taurine to the UDCA molecule dramatically improves water solubility and GI stability compared to UDCA alone, producing superior oral bioavailability and broader tissue distribution.†
TUDCA's documented biological activities span a range that makes it one of the most physiologically versatile compounds in the nutraceutical space — liver protection and regeneration, bile flow optimization, neuroprotection, gut barrier integrity, mitochondrial protection, insulin sensitization, and cardiovascular support all have published research support for TUDCA specifically. This breadth reflects TUDCA's fundamental mechanism: it is a potent endoplasmic reticulum (ER) stress inhibitor — it protects cells from the unfolded protein response (UPR) that drives cell death in virtually every disease context, from liver disease to neurodegenerative conditions to metabolic disorders.†
The Six Documented Support Areas — What the Research Shows
Liver Health — The Primary Application
TUDCA's most extensively documented application is hepatoprotection and liver health support. Pharmaceutical UDCA has been the standard of care for primary biliary cholangitis (a progressive liver disease) for decades — TUDCA, as the more bioavailable taurine conjugate, demonstrates comparable or superior efficacy in research. The mechanisms are multiple: TUDCA replaces the toxic hydrophobic bile acids that accumulate in cholestatic liver disease with less toxic hydrophilic bile acids, reducing bile acid-induced hepatocyte death. TUDCA directly inhibits apoptosis in liver cells through both mitochondrial and ER stress pathways. It upregulates hepatocyte survival signaling through AKT and Bcl-2 pathways. Research on TUDCA specifically documents improvements in liver enzyme levels (ALT, AST, GGT), improvements in liver histology, and reductions in liver fibrosis markers across multiple liver disease contexts.†
For Get Yok'd customers, the most practical applications are: on-cycle liver support during prohormone cycles (TUDCA addresses the hepatocyte stress from prohormone first-pass metabolism more directly than Milk Thistle alone), post-cycle liver recovery, alcohol-associated liver stress, and general daily liver maintenance for individuals running comprehensive supplement stacks that increase the liver's detoxification burden.†
Gallbladder and Bile Flow Support
TUDCA directly modulates bile composition — it is a hydrophilic bile acid that dilutes and partially replaces the toxic hydrophobic bile acids that contribute to gallstone formation and cholestatic liver disease. By increasing the water-soluble bile acid fraction and improving bile flow from the liver through the biliary tract, TUDCA supports gallbladder function and reduces the biliary stasis that contributes to gallstone formation. Hi-Tech specifically notes on the product's back label that TUDCA increases natural bile salt levels — this choleretic effect (bile flow stimulation) supports fat digestion and the excretion of fat-soluble toxins processed by the liver.†
Neuroprotection — The Emerging Research Frontier
TUDCA's neuroprotective properties are among the most actively researched areas of TUDCA science. The mechanism connects to TUDCA's fundamental ER stress inhibition — neurons are highly sensitive to ER stress because of their high protein synthesis demands and their post-mitotic nature (neurons that die are not replaced). Research on TUDCA in models of Parkinson's disease, Alzheimer's disease, ALS, Huntington's disease, retinitis pigmentosa, and stroke has consistently documented neuroprotective effects through TUDCA's ability to reduce apoptosis in neurons under ER stress conditions. Human clinical research on TUDCA in ALS patients documented significant slowing of disease progression. In animal models of retinal degeneration, TUDCA preserved photoreceptor function at doses translatable to human supplemental use. The memory and brain support claim on Hi-Tech's label reflects this neuroprotective research base.†
Gut Health and Digestive Function
TUDCA protects intestinal epithelial cells from ER stress-induced apoptosis — the same mechanism that preserves liver and neuronal cells operates in the gut lining, supporting intestinal barrier integrity and reducing the gut permeability that drives systemic inflammation. TUDCA also has anti-inflammatory effects on intestinal tissue through inhibition of NF-κB signaling, and its choleretic bile flow support improves fat digestion and the absorption of fat-soluble vitamins and compounds throughout the GI tract.†
Insulin Sensitivity and Metabolic Health
Research has documented TUDCA's ability to improve insulin sensitivity through ER stress reduction in pancreatic beta cells (which secrete insulin) and in peripheral tissues. Chronic ER stress in pancreatic beta cells is a primary mechanism of beta cell loss in Type 2 diabetes progression — TUDCA's ER stress inhibition preserves beta cell function and insulin secretory capacity. A human clinical study published in Diabetes (Kars et al., 2010) documented that TUDCA supplementation for 4 weeks significantly improved both hepatic and peripheral insulin sensitivity in obese humans — effects comparable to some pharmaceutical insulin sensitizers at similar magnitudes.†
Cardiovascular and Immune Support
TUDCA supports cardiovascular function through its anti-apoptotic effects on cardiac cells under ischemic stress — research has documented reduced infarct size and improved cardiac function when TUDCA is present during cardiac ischemia-reperfusion events. Immune support reflects TUDCA's broad ER stress inhibition across immune cells, maintaining immune cell function during physiological stress states that would otherwise trigger apoptosis in lymphocytes and macrophages.†
TUDCA vs. Milk Thistle — Different Mechanisms, Complementary Coverage
TUDCA and Milk Thistle (Silymarin) are both hepatoprotective compounds but operate through entirely different mechanisms. Silymarin blocks hepatotoxin entry into liver cells, stimulates hepatocyte regeneration, and acts as a hepatic antioxidant. TUDCA directly modifies bile composition, inhibits ER stress-induced apoptosis in hepatocytes, and replaces toxic hydrophobic bile acids with cytoprotective hydrophilic ones. The two mechanisms are complementary rather than redundant — Silymarin addresses oxidative and toxin-mediated liver damage while TUDCA addresses the bile acid and ER stress-mediated pathways of liver cell death. For prohormone users running comprehensive on-cycle support, stacking TUDCA with Liver Rx (which contains Milk Thistle and NAC) provides broader coverage than either product alone.†
Hi-Tech's Hi-Potency Positioning — Why 250mg Per Capsule
Hi-Tech designates this product as "Hi-Potency" at 250mg TUDCA per capsule. The therapeutic doses used in most positive TUDCA research range from 250mg to 1,750mg daily depending on the condition being studied — 500mg daily (2 capsules at the recommended twice-daily dose) is within the range used in published studies documenting liver enzyme improvements, insulin sensitivity effects, and neuroprotective outcomes at supplemental doses. Pharmaceutical UDCA for primary biliary cholangitis is dosed at 13-15mg/kg body weight daily — for a 180lb individual that translates to approximately 1,060-1,225mg daily. Hi-Tech's 500mg daily at the twice-daily dose is at the lower-to-middle end of the therapeutic range but represents meaningful biological activity for liver health maintenance, on-cycle support, and general wellness applications.†
Frequently Asked Questions
How does Hi-Tech TUDCA compare to other liver support products?
TUDCA is mechanistically distinct from every other liver support compound Get Yok'd carries. Milk Thistle (in NutraKey Liver Optima, MuscleSport Liver & Kidney, and Hi-Tech Liver Rx) works through antioxidant protection and hepatotoxin blocking. NAC works through glutathione replenishment. Artichoke Extract works through choleretic bile flow stimulation. TUDCA works through bile acid composition modification and ER stress inhibition — a cellular survival pathway that none of the botanical liver support compounds address. It is complementary to all of them and adds a mechanistic dimension that none of them provide independently.†Why is TUDCA specifically recommended for prohormone on-cycle support?
Prohormone compounds are processed through hepatic first-pass metabolism even with improved delivery systems — this processing generates reactive intermediates and increases the oxidative and ER stress burden on hepatocytes. TUDCA's specific value in this context is its direct hepatocyte protection from ER stress-induced apoptosis, its improvement of bile flow to facilitate the excretion of fat-soluble metabolites, and its anti-apoptotic effects on liver cells under metabolic stress. Combined with Milk Thistle (Silymarin for oxidative protection) and NAC (for glutathione replenishment), TUDCA provides the third mechanistic pillar of comprehensive on-cycle liver protection.†How long should TUDCA be taken and can it be used long-term?
TUDCA has an established long-term safety profile in clinical research — pharmaceutical UDCA has been used continuously for years in primary biliary cholangitis patients. At supplemental doses (250-500mg daily), TUDCA is generally considered appropriate for continuous use as a liver health maintenance supplement. For on-cycle prohormone support, take throughout the cycle and extend into PCT. Consult a physician for guidance on longer-term use if you have a pre-existing liver condition or are taking prescription medications that affect bile acid metabolism.†Is Hi-Tech TUDCA appropriate for daily liver maintenance, not just on-cycle?
Yes — TUDCA's documented benefits for bile flow, gut health, insulin sensitivity, and neuroprotection make it a relevant daily supplement for general wellness beyond the on-cycle support application. Individuals who drink alcohol regularly, take medications processed by the liver, have been diagnosed with elevated liver enzymes, or simply want comprehensive daily liver support beyond Milk Thistle will find TUDCA a meaningful addition to a daily wellness protocol.†
How to Take Hi-Tech Pharmaceuticals TUDCA
Take 1 capsule twice daily with 8-12oz of water, or as directed by your healthcare professional. Taking with meals may improve GI tolerance. For on-cycle prohormone support: take throughout the prohormone cycle alongside Liver Rx or Gear Support and extend into PCT. For general daily liver maintenance: one or two capsules daily with meals. Do not exceed the recommended dose without physician guidance. Not for pregnant or nursing women. Consult a physician before use if taking prescription medications — particularly those affecting bile acid metabolism (cholestyramine, colestipol) or immunosuppressants. Individuals with active gallstones or bile duct obstruction should consult a physician before use. California Prop 65 Warning applies.†
Why Buy at Get Yok'd
Real-time inventory across all five Southern California stores
Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
Authorized Hi-Tech Pharmaceuticals retailer — carrying the full Hi-Tech nutraceutical lineup
Staff who can help you build a complete on-cycle support stack incorporating TUDCA alongside Liver Rx, NAC, and Arimistane in person at any location
One of the best loyalty programs in the supplement industry — earn rewards on every purchase
Who Should Exercise Caution with TUDCA
Not for pregnant or nursing women without physician clearance
Individuals with active gallstones or bile duct obstruction should consult a physician before use — TUDCA affects bile flow and composition
Individuals taking cholestyramine or colestipol (bile acid sequestrants) should not take TUDCA within 4 hours of these medications — they may bind TUDCA in the GI tract and reduce its absorption
Individuals with end-stage liver disease should consult a hepatologist before use
Individuals with diarrhea-predominant conditions should use with caution — TUDCA's choleretic and osmotic effects in the colon may exacerbate loose stools in some individuals
Consult a physician before use if taking any prescription medications
Not for persons under 18 without physician guidance
California Prop 65 Warning applies.
Keep out of reach of children.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.