NutraBio - Magnesium Glycinate

NutraBio Magnesium Glycinate is exactly what magnesium supplementation should be: a single, clinically superior form of magnesium in a clean, no-filler capsule with nothing unnecessary added. Powered by Albion magnesium bisglycinate chelate — the patented, pharmaceutical-grade chelated magnesium form recognized as the gold standard for absorption, tolerability, and efficacy — this formula delivers everything magnesium is known for without the digestive side effects that make inferior magnesium forms difficult to use consistently. Available in capsules (30 servings) and powder (50 servings). Made in the USA. GMP-certified. Third-party tested. Non-GMO, gluten-free, soy-free, vegetarian.†

Supplement Facts — NutraBio Magnesium Glycinate

• Active Ingredient: Magnesium (as Albion Magnesium Bisglycinate Chelate)
• No fillers. No excipients. No additives. No artificial anything.
• Non-GMO. Gluten-free. Soy-free. Vegetarian capsules.
• Kosher and Halal certified.
• Made in USA in NutraBio's own GMP-certified, pharmaceutical-grade manufacturing facility.
• Third-party tested for purity and potency.
• Available as capsules (30 servings) or powder (50 servings).

What's Inside NutraBio Magnesium Glycinate — Why Albion Bisglycinate Is Different

The Magnesium Deficiency Problem

Magnesium is the fourth most abundant mineral in the human body and is required as a cofactor for over 600 enzymatic reactions — essentially every major metabolic pathway depends on it at some point. It is directly involved in ATP synthesis, DNA and RNA synthesis, protein production, nerve impulse transmission, muscle contraction and relaxation, blood glucose regulation, calcium and potassium transport across cell membranes, and the regulation of cortisol and stress hormones. There is virtually no system in the body that functions optimally without adequate magnesium.†

The problem is that adequate magnesium is genuinely difficult to maintain through diet alone in the modern food environment. Magnesium content in soil has declined significantly over decades of agricultural practices, meaning the produce, grains, and plant foods that historically provided meaningful magnesium contain significantly less than they once did. Processing removes additional magnesium from grains and packaged foods. Intense exercise depletes magnesium through sweat and urine at rates that meaningfully exceed typical dietary intake. Alcohol consumption accelerates magnesium excretion. Certain medications — including diuretics, proton pump inhibitors, and antibiotics — reduce magnesium absorption or increase losses. As a result, research consistently estimates that up to 75% of American adults do not meet the Recommended Daily Allowance for magnesium, making it one of the most common and most consequential nutritional deficiencies in the population.†

Why Form Matters — The Problem with Cheap Magnesium

Not all magnesium supplements are equivalent, and the differences in bioavailability between forms are substantial enough to determine whether a product produces real-world effects or simply passes through the digestive system. The most common and cheapest form of magnesium found in supplements is magnesium oxide — it contains a high percentage of magnesium by weight on paper (approximately 60%), but research shows magnesium oxide has bioavailability of only 4% in healthy adults. The other 96% reaches the colon unabsorbed, where it draws water osmotically and causes the laxative effect that makes magnesium supplements a bathroom emergency for many people. A 400mg magnesium oxide tablet delivers approximately 16mg of actual absorbed magnesium — functionally useless for addressing deficiency.†

Magnesium citrate is a meaningful improvement over oxide, with bioavailability around 25-30% — better, but still limited by the same mechanism: magnesium citrate is moderately well-absorbed but carries the same laxative risk at higher doses because unabsorbed magnesium draws water in the colon. It is a workable option for mild supplementation but not for consistent higher-dose use.†

Magnesium bisglycinate chelate — the form in NutraBio Magnesium Glycinate — operates through an entirely different absorption mechanism that bypasses the limitations of both oxide and citrate. In chelation, the magnesium ion is chemically bonded to two glycine amino acid molecules. Glycine is one of the most readily absorbed compounds in the small intestine, actively transported by specific amino acid carrier proteins rather than relying on passive diffusion. Because the magnesium is bonded to glycine, the intestine transports it via the glycine pathway — meaning it is absorbed far more efficiently, does not accumulate in the colon to cause osmotic laxative effects, and reaches systemic circulation at dramatically higher rates than non-chelated forms.†

Albion Magnesium Bisglycinate Chelate — The Patented Gold Standard

Not all magnesium glycinate products are equal even within the bisglycinate category, because the quality of the chelation process matters significantly for the stability and actual bioavailability of the final compound. Albion Minerals (now Balchem Corporation) has been the industry leader in pharmaceutical-grade mineral chelation for decades, holding numerous patents on the chelation chemistry that produces true, stable amino acid chelates that maintain their bonded structure through the digestive process.†

The key distinction of Albion's TRAACS (The Real Amino Acid Chelate System) technology is that the magnesium-glycine bond is formed under specific controlled conditions that produce a genuine chelate with defined molecular weight and stability — meaning the bond holds together through the acidic environment of the stomach and survives to be absorbed intact in the small intestine via the amino acid transporter pathway. Generic "magnesium glycinate" products on the market frequently use lower-quality processes that produce partial chelates or simple physical mixtures of magnesium salts and glycine that are not truly bonded — these behave more like magnesium salts in the digestive system rather than true chelates, with the corresponding reduction in bioavailability and increase in gastrointestinal side effects.†

NutraBio's exclusive use of Albion chelate in Magnesium Glycinate means every capsule contains confirmed, pharmaceutical-grade chelated magnesium that absorbs through the superior glycine amino acid transporter pathway — not a budget substitute that calls itself bisglycinate on the label while performing like magnesium oxide in the body.†

What Magnesium Bisglycinate Supports

Muscle relaxation and recovery. Magnesium regulates calcium ion flux in muscle cells — it is the physiological "off switch" for muscle contraction. When calcium floods muscle cells, contraction occurs; magnesium pumps calcium back out, allowing relaxation. Inadequate magnesium disrupts this calcium-magnesium balance, contributing to muscle cramps, spasms, tightness, and difficulty fully relaxing between contractions. Athletes who train intensely and lose significant magnesium through sweat are particularly vulnerable to this effect. Magnesium bisglycinate supplementation helps restore the calcium-magnesium balance that efficient muscle function and post-training recovery require.†

Sleep quality and relaxation. Magnesium modulates the GABA (gamma-aminobutyric acid) receptor system — the primary inhibitory neurotransmitter system responsible for reducing neuronal excitability and producing a calm, relaxed mental state. Magnesium acts as a natural NMDA receptor antagonist, reducing excitatory neurotransmission, and supports the body's transition from an activated, cortisol-dominant state to the parasympathetic rest-and-digest state needed for quality sleep. The glycine component of magnesium bisglycinate adds additional sleep-supporting properties, as glycine itself has been studied for its ability to reduce core body temperature and improve sleep onset and quality. The combination produces a meaningful pre-sleep supplement that works through multiple mechanisms without any sedative or dependency risk.†

Nervous system balance and stress resilience. Magnesium acts as a physiological buffer against the cortisol stress response. Research documents a bidirectional relationship between magnesium and stress: stress depletes magnesium through increased urinary excretion, while magnesium deficiency increases sensitivity to stress and amplifies cortisol output. Chronic stress and chronic magnesium deficiency therefore create a self-reinforcing cycle. Consistent magnesium supplementation interrupts this cycle by restoring the magnesium levels that support healthy hypothalamic-pituitary-adrenal (HPA) axis regulation — the system that governs the body's stress response.†

Bone health and mineral balance. Magnesium is directly required for the conversion of vitamin D to its active form (calcitriol) and for the functioning of parathyroid hormone — the primary regulators of calcium metabolism. Without adequate magnesium, the body cannot efficiently use vitamin D or regulate calcium, regardless of how much of either is consumed. The common recommendation to take calcium and vitamin D together for bone health is incomplete without magnesium as the third essential element in the calcium-vitamin D-magnesium axis.†

Energy production and glucose metabolism. ATP — the cell's primary energy currency — must be bound to magnesium to be biologically active. Every ATP-dependent reaction in the body (and there are hundreds, spanning muscle contraction, protein synthesis, DNA replication, and cell signaling) requires magnesium as a cofactor. Magnesium also enhances insulin receptor sensitivity, supporting glucose uptake by cells. For athletes and active individuals, the energy production role of magnesium is as important as any other mineral in their supplement protocol.†

Cardiovascular function. Magnesium supports heart rhythm regulation by maintaining proper electrical conductance in cardiac muscle. It also supports healthy blood pressure by promoting relaxation of vascular smooth muscle and modulating the renin-angiotensin-aldosterone system. Research consistently associates adequate magnesium status with healthier cardiovascular outcomes.†

Frequently Asked Questions About NutraBio Magnesium Glycinate

1. Why does NutraBio use Albion chelate instead of generic magnesium glycinate?
   The quality of mineral chelation determines whether a product actually works. Albion's TRAACS chelation technology produces a confirmed, stable magnesium-glycine bond that maintains its structure through the digestive process and absorbs via the amino acid transporter pathway in the small intestine. Generic magnesium glycinate products frequently use lower-quality mixing processes that produce partial chelates or simple physical mixtures that absorb more like conventional magnesium salts — with lower bioavailability and more GI side effects. NutraBio uses Albion specifically because it is the independently verified, patented form with demonstrated superiority over alternatives. This is the same decision they apply to every ingredient across their product line: when a better form exists and can be verified, use the better form.†
2. When is the best time to take magnesium glycinate?
   Most people get the most subjectively noticeable benefit from taking magnesium glycinate in the evening, 30-60 minutes before bed. Evening use targets the sleep quality and nervous system relaxation benefits most directly — magnesium's GABA-modulating and NMDA-antagonist properties support the physiological transition to sleep, and the glycine component independently supports lower core body temperature and improved sleep onset. Post-workout use is also highly effective for athletes — magnesium losses through sweat during training make immediate post-session repletion particularly relevant for muscle relaxation and recovery. Morning use is appropriate for those who want to address the deficiency and support ATP-dependent energy metabolism throughout the day. All of these are valid use windows; choose based on what you are primarily trying to support.†
3. Does magnesium glycinate cause digestive issues?
   Magnesium bisglycinate chelate is the form of magnesium least likely to cause digestive side effects. Because it absorbs via the amino acid transporter pathway in the small intestine rather than relying on passive diffusion, significantly less unabsorbed magnesium reaches the colon where osmotic laxative effects occur. Most people who have experienced diarrhea from magnesium oxide or even magnesium citrate tolerate magnesium bisglycinate chelate without any gastrointestinal issues at recommended doses. This is one of the primary clinical advantages of the chelated glycinate form and a key reason it is the preferred magnesium form for consistent daily supplementation.†
4. Who benefits most from magnesium glycinate supplementation?
   Given that up to 75% of Americans do not meet the RDA for magnesium, the honest answer is most people. Within that broad population, the groups most likely to see the strongest and fastest subjective improvement are: athletes training at high intensity who lose magnesium through sweat (muscle cramps, poor recovery, and sleep quality issues are common early signs of magnesium depletion in this group); individuals who experience chronic stress and notice difficulty winding down, elevated tension, or disrupted sleep; anyone using medications that reduce magnesium absorption or increase losses; individuals who drink alcohol regularly; and people over 50, for whom magnesium deficiency is more common and the bone health, cardiovascular, and insulin sensitivity roles of magnesium become more consequential. For anyone taking vitamin D supplements, magnesium glycinate is the essential cofactor that allows vitamin D to function properly — supplementing vitamin D without adequate magnesium is physiologically incomplete.†

How to Take NutraBio Magnesium Glycinate

Take 1 serving daily with or without food. Most users prefer evening use, 30-60 minutes before bed, to support sleep quality and overnight muscle recovery. Can be taken post-workout for acute magnesium repletion after training-induced losses. Consistent daily use over 1-2 weeks is required to meaningfully restore magnesium levels in deficient individuals — do not evaluate effectiveness based on single-dose response. Stacks well with Zinc, Vitamin D3, Omega-3, and any protein or recovery supplement.†

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Who Should Not Take NutraBio Magnesium Glycinate

• Do not use if pregnant or nursing without physician guidance
• Consult a physician before use if you have kidney disease — kidneys regulate magnesium excretion, and individuals with impaired kidney function can accumulate magnesium to potentially dangerous levels
• Consult a physician before use if taking medications that interact with magnesium, including certain antibiotics, diuretics, diabetes medications, or heart medications
• Do not exceed recommended dose without physician guidance
• Not for use by persons under 18 without physician guidance
• Keep out of reach of children

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.