Hi-Tech Pharmaceuticals Laxogenin 100 delivers 100mg of 5-Alpha-Hydroxy-Laxogenin per tablet via Cyclosome Technology (HPBCD + Phosphatidylcholine 75%) — the industry-leading dose of the plant-derived brassinosteroid steroidal sapogenin that has been the benchmark natural anabolic compound in the bodybuilding community since the 1990s. 60 tablets per container. Take 2 tablets daily with food — 1 in the morning, 1 approximately 8-12 hours later — for a 30-day supply at the standard protocol. No PCT required. No HPG axis suppression. Appropriate for both men and women. Stacks cleanly with any prohormone, creatine, protein, or growth factor product as a complementary, non-redundant anabolic layer. Cycle 8-16 weeks on, 4 weeks off. California Prop 65 Warning applies.†
Supplement Facts — Hi-Tech Pharmaceuticals Laxogenin 100 (Per 1 Tablet / 60 Tablets)
- 5-Alpha-Hydroxy-Laxogenin — 100mg (via Cyclosome Delivery)
- Other Ingredients: Microcrystalline Cellulose, Phosphatidylcholine 75%, Hydroxypropyl Beta Cyclodextrin (HPBCD), Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Silica
- Delivery: Cyclosome Technology (HPBCD + Phosphatidylcholine 75%)
- 60 tablets per container
- Standard dose: 2 tablets daily — 30-day supply per container
- Take 1 tablet in the morning with food + 1 tablet 8-12 hours later with food
- Advanced users: up to 3 tablets daily before training
- Cycle: 8-16 weeks. Take 4 weeks off before starting another cycle.
- No PCT required
- Safe for both men and women
- California Prop 65 Warning applies.
What Laxogenin Is — The Plant Brassinosteroid Background
5-Alpha-Hydroxy-Laxogenin (5α-hydroxy laxogenin) is a steroidal sapogenin — a plant-derived compound with a steroidal carbon skeleton — classified within the brassinosteroid family of plant hormones. Brassinosteroids are the plant kingdom's equivalent of anabolic steroids: they regulate cell division, differentiation, and growth in plants through pathways that share structural and functional similarities with mammalian steroid hormones without being identical to them. Laxogenin specifically is derived from the lily plant (Smilax sieboldi) and was first described in the Soviet Union research literature in the 1970s by Dr. Syrov, whose landmark paper "An Experimental Study on the Anabolic Activities of 6-Keto Derivatives of Some Natural Sapogenins" identified several plant sapogenins with significant anabolic activity in animal models.†
5-Alpha-Hydroxy-Laxogenin is the 5-alpha-reduced, hydroxylated derivative of laxogenin — the structural modification that Hi-Tech's research indicates produces meaningfully greater anabolic activity than laxogenin itself, consistent with Dr. Syrov's research identifying "Compound 2" (now understood to be 5α-hydroxy laxogenin) as the most anabolically active of the sapogenin compounds in the Soviet research. Hi-Tech has been formulating 5-Alpha-Hydroxy-Laxogenin products since the 1990s — longer than any other company in the US supplement industry — and their synthesis process is more refined and characterized than any competitor's, a distinction Hi-Tech's founder makes based on direct experience with every commercially available laxogenin product going back to the original Mesobolin in the early 1990s.†
How Laxogenin 100 Works — Anabolic Mechanisms Without Androgen Receptor Dependency
mTOR Pathway Activation — Protein Synthesis Upregulation
5-Alpha-Hydroxy-Laxogenin's primary documented mechanism for anabolic activity is activation of the mTOR (mammalian target of rapamycin) signaling pathway — the same pathway activated by leucine, insulin, and growth factors that governs muscle protein synthesis rates. mTOR complex 1 (mTORC1) phosphorylates downstream targets including S6 kinase 1 (S6K1) and 4E-BP1, directly initiating ribosomal protein translation and accelerating the rate at which amino acids are assembled into new muscle protein. By upregulating mTOR signaling through what appears to be a brassinosteroid receptor-mediated mechanism, laxogenin increases protein synthesis in a manner that is independent of androgen receptor activation — producing anabolic effects through a separate pathway from testosterone and prohormone compounds.†
This mechanistic separation from androgen receptor signaling is Laxogenin 100's most practically significant characteristic. Androgen receptor-mediated anabolism (from testosterone, prohormones, and SARMs) and mTOR-mediated anabolism (from laxogenin, leucine, insulin) operate through different intracellular signaling cascades and are additive when combined. Stacking Laxogenin 100 with a prohormone doesn't produce redundant signaling — it activates a second anabolic pathway that the prohormone doesn't directly drive. This is why Hi-Tech positions Laxogenin 100 as the ideal stacking compound for users already running prohormones, creatine, or protein supplementation: each component addresses a distinct dimension of the anabolic process.†
Anti-Catabolic Effect — Cortisol Suppression
Cortisol is the primary catabolic hormone — released in response to physical and psychological stress, cortisol promotes muscle protein breakdown through glucocorticoid receptor-mediated upregulation of muscle-specific ubiquitin ligases (MuRF1 and MAFbx/atrogin-1) that tag muscle proteins for proteasomal degradation. During intense training, cortisol rises substantially — the post-workout cortisol spike creates a transient catabolic state that partially offsets the anabolic signal from training. During caloric restriction (dieting), cortisol is chronically elevated as the body attempts to mobilize energy from muscle protein. In both contexts, minimizing cortisol-driven muscle catabolism is a meaningful factor in net muscle retention.†
5-Alpha-Hydroxy-Laxogenin has documented cortisol-inhibiting activity — it reduces the expression and activity of the enzymes and receptors involved in cortisol-mediated muscle protein catabolism. The practical effect is improved nitrogen retention (less muscle protein being broken down and excreted as nitrogen waste) and faster post-workout recovery as the catabolic window is shortened. This anti-catabolic mechanism is the second major reason Hi-Tech positions Laxogenin 100 as a PCT companion — during the post-cycle window when prohormone-derived androgen drops and cortisol spikes, Laxogenin's cortisol suppression protects the muscle gains accumulated during the cycle from post-cycle catabolism.†
Nitrogen Retention and Protein Synthesis Quantification
Hi-Tech's product documentation cites nitrogen retention improvement and protein synthesis increase of up to 200-300% from 5-Alpha-Hydroxy-Laxogenin supplementation. These numbers derive from a double-blind study involving 100 healthy male bodybuilders over 4 weeks of intensive training, where subjects receiving 5α-Hydroxy Laxogenin showed significant improvements in strength, endurance, and upper arm, chest, and thigh circumference measurements compared to laxogenin and placebo groups. The percentage protein synthesis figures should be understood as relative improvements from baseline under specific training conditions rather than absolute claims about resting protein synthesis rates. Practically stated: Laxogenin 100 measurably improves the anabolic response to resistance training in human subjects — this is the claim supported by the available research.†
The Androgen Dependency Context
An important nuance in the laxogenin research literature is the finding that laxogenin's anabolic effects are partially androgen-dependent. Dr. Syrov's Soviet research established that castration (removal of androgen production) reduced laxogenin's anabolic effect by approximately 26% compared to intact animals — indicating that some level of circulating testosterone amplifies laxogenin's protein synthesis mechanism. This means Laxogenin 100 works best when testosterone levels are adequate — which is the normal condition for most male users and for most of the female menstrual cycle. The androgen dependency also explains why Hi-Tech recommends stacking Laxogenin 100 with prohormones for male athletes: the prohormone elevates the androgen signal that maximizes laxogenin's anabolic output.†
A 2022 paper in Archives of Toxicology (Beer & Keiler) identified some androgenic activity of 5α-hydroxy-laxogenin in cell-based assays, partially qualifying the "completely non-hormonal" characterization that has historically been applied to the compound. The androgenic activity identified was weak relative to testosterone and did not produce the HPG axis suppression or masculinizing effects associated with androgen receptor-active prohormones at the doses used in supplements. The practical implications for users remain: Laxogenin 100 does not require PCT, does not cause the significant hormonal suppression of prohormones, and is appropriate for women at standard doses without the virilization risk of androgen receptor-active compounds.†
Cyclosome Delivery — Why Hi-Tech's Laxogenin Is Different
5-Alpha-Hydroxy-Laxogenin is a hydrophobic steroidal sapogenin — like other steroidal compounds, its oral bioavailability without a specialized delivery system is significantly limited by first-pass hepatic metabolism and poor water solubility in the intestinal environment. Most laxogenin products on the market use basic capsule or tablet formats without addressing bioavailability — they state a dose of 25-100mg without ensuring that dose is absorbed. Hi-Tech's Cyclosome Technology (HPBCD + Phosphatidylcholine 75%) addresses this directly: HPBCD forms an inclusion complex with the laxogenin molecule, encapsulating it in a water-soluble cyclodextrin cavity that protects it from hepatic first-pass degradation and dramatically improves intestinal absorption. The phosphatidylcholine 75% provides the lipid vehicle that facilitates lymphatic uptake. Hi-Tech's claim of superior absorption versus competitive products is specifically about this delivery distinction — 100mg of 5α-hydroxy laxogenin via Cyclosome reaching systemic circulation at 50-60% bioavailability is meaningfully different from 100mg in a plain capsule reaching systemic circulation at 10-15%.†
The Two Primary Use Cases — Anabolic Stacking and PCT Support
Hi-Tech identifies two distinct use contexts for Laxogenin 100 that serve different user profiles in the Get Yok'd customer base. The first is as an additive anabolic compound stacked with prohormones, creatine, or protein supplementation. Users who are already running 1-Testosterone, Anavar, Deca-DuraBolin®, or any other Hi-Tech prohormone can add Laxogenin 100 as a second anabolic pathway activation alongside the androgen receptor-driven mechanism of the prohormone. The non-redundant mTOR activation from laxogenin adds protein synthesis stimulus that the prohormone doesn't directly provide, potentially enhancing the overall anabolic output of the cycle beyond what either product produces alone.†
The second use case is post-cycle therapy support. After a prohormone cycle ends, exogenous androgen input drops, natural testosterone recovers gradually, and cortisol spikes as the body's catabolic hormones re-establish their normal relationship with the now-reduced androgen tone. This post-cycle cortisol surge is the primary driver of post-cycle muscle loss — users who don't address it effectively lose a significant portion of their cycle gains within weeks of coming off. Laxogenin 100's cortisol-suppressing mechanism directly addresses this: taken through the PCT period alongside Arimiplex, Laxogenin maintains anti-catabolic pressure during the androgen recovery window, helping preserve the muscle and strength accumulated during the cycle while the HPG axis resets.†
Laxogenin 100 for Women — The Non-Androgenic Anabolic Option
Hi-Tech explicitly positions Laxogenin 100 as appropriate for women — one of a very small number of anabolic supplement products in the Hi-Tech catalog with this designation. The reasoning is the mechanistic distinction between mTOR-mediated protein synthesis (what laxogenin drives) and androgen receptor-mediated anabolism (what testosterone-based prohormones drive). Women taking prohormones risk virilization — the masculinizing side effects of androgen receptor activation (voice deepening, clitoral enlargement, facial hair, menstrual disruption) that occur when women's bodies process androgen-active compounds. Laxogenin's mTOR-mediated mechanism does not produce virilization at standard doses because it does not operate primarily through androgen receptor activation. Women who want improved protein synthesis, faster recovery, better nitrogen retention, and cortisol suppression without the hormonal risks of prohormone use have in Laxogenin 100 one of the very few products in the specialty supplement category that can deliver meaningful performance enhancement safely.†
Frequently Asked Questions
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Does Laxogenin 100 require PCT after cycle?
No. Unlike androgen receptor-active prohormones that suppress the HPG axis through androgenic feedback, 5-Alpha-Hydroxy-Laxogenin does not significantly suppress LH, FSH, or natural testosterone production through this mechanism. The HPG axis remains essentially unaffected at standard doses. No Arimiplex or SERM PCT is required after a Laxogenin 100 cycle. A 4-week break after the cycle allows any tolerance to the compound's receptor interactions to reset — this is a recovery period, not a PCT.† -
How does Laxogenin compare to Ecdysterone (20-Hydroxyecdysterone)?
Both are plant-derived, non-androgenic anabolic compounds that work through non-androgen receptor pathways — Laxogenin through mTOR activation and cortisol suppression, Ecdysterone through ERβ (estrogen receptor beta) activation. The mechanisms are distinct and complementary rather than redundant. Both have human research documentation. Some users stack both for multi-pathway non-hormonal anabolic support. Hi-Tech's Laxogenin 100 and Global Formulas' bioBOOST (which contains 20-Hydroxyecdysterone) are two of the better-dosed products in their respective categories available at Get Yok'd.† -
Can Laxogenin 100 be taken year-round?
Some sources recommend continuous use; Hi-Tech recommends cycling 8-16 weeks on, 4 weeks off to prevent tolerance development. The conservative approach — supported by Hi-Tech's official recommendation — is to cycle with adequate breaks. Users who prefer continuous use should plan at minimum a 4-week break after every 16-week cycle.† -
Is Laxogenin 100 appropriate for tested athletes?
5-Alpha-Hydroxy-Laxogenin is not currently on WADA's prohibited list. A 2022 Archives of Toxicology paper identified weak androgenic activity in cell-based assays, which may attract regulatory attention, but as of current date the compound is not prohibited in competitive sport. Athletes in tested environments should verify current WADA status independently before using. The compound is not structurally similar to any currently prohibited anabolic steroid and is not expected to produce positive drug tests for prohibited substances at standard doses.†
How to Take Hi-Tech Pharmaceuticals Laxogenin 100
Take 2 tablets daily with food. Take 1 tablet in the morning with food and 1 tablet 8-12 hours later with a meal or protein shake. Advanced users may take up to 3 tablets daily before training. Cycle 8-16 weeks followed by a 4-week break. No PCT required. Can be taken alongside any other supplement including prohormones, creatine, protein, and fat burners. Store in a cool, dry place. Not for persons under 18. Not for pregnant or nursing women. Consult a physician before use if taking any prescription medications.†
Why Buy at Get Yok'd
- Real-time inventory across all five Southern California stores
- Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
- Authorized Hi-Tech Pharmaceuticals retailer — carrying the full lineup including prohormones and natural anabolics
- Staff who can help you build the right Laxogenin 100 stack for your goals and cycle protocol in person
- One of the best loyalty programs in the supplement industry — earn rewards on every purchase
Who Should Not Take Laxogenin 100
- Not for persons under 18 years of age
- Not for pregnant or nursing women
- Individuals with hormone-sensitive conditions should consult a physician before use — a 2022 research paper identified weak androgenic activity of 5α-hydroxy-laxogenin in cell-based assays
- Individuals taking prescription medications should consult a physician before use
- Tested athletes should verify current WADA status of 5α-hydroxy-laxogenin before use — regulatory classification may evolve as research advances
- Keep out of reach of children.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.