NutraBio Unbound Bloodline is the hardcore pump formula from NutraBio's Unbound Series — built for lifters who approach blood flow and vascularity as a primary training objective, not an afterthought. Six precision-dosed ingredients across four distinct vasodilation mechanisms: nitric oxide production, osmotic cellular hydration, ACE enzyme inhibition, and endothelial peptide signaling. 8g pure L-Citrulline. 3g HydroPrime glycerol. 508mg VasoDrive-AP. 200mg PeptiPump. 200mg Pine Bark Extract. 50mg AstraGin. Zero stimulants. Zero caffeine. 20 servings. This is what a purpose-built pump formula looks like when the manufacturer has a 30-year track record of not cutting doses.†
Full Supplement Facts — NutraBio Unbound Bloodline (Per 1 Scoop Serving)
- L-Citrulline — 8,000mg
- HydroPrime Glycerol (standardized to 65% glycerol) — 3,000mg
- VasoDrive-AP (Casein Hydrolysate — IPP + VPP Lactotripeptides) — 508mg
- PeptiPump (Peptide Vasodilation Complex) — 200mg
- Pine Bark Extract — 200mg
- AstraGin (Panax notoginseng + Astragalus membranaceus) — 50mg
- Zero stimulants. Zero caffeine. Fully transparent label. No proprietary blends.
- Made in the USA. GMP-certified pharmaceutical-grade facility. Third-party tested.
- 20 servings per container.
What's Inside NutraBio Unbound Bloodline — Four Pump Mechanisms, One Formula
Most pump pre-workouts work through a single mechanism — typically nitric oxide production via citrulline. Bloodline covers four distinct physiological pathways simultaneously, which is why the pump it produces is qualitatively different from a single-mechanism formula at the same citrulline dose. Each ingredient addresses a separate aspect of how blood flow and muscle fullness are generated and sustained.†
Mechanism 1 — Nitric Oxide Production: L-Citrulline — 8,000mg
Pure L-Citrulline at 8g is the highest practical dose used in pump formulas with genuine research backing, and it is the foundation everything else in Bloodline builds on. Citrulline is converted in the kidneys to L-Arginine more efficiently than supplemental arginine itself — bypassing the intestinal and liver metabolism that destroys most orally supplemented arginine before it reaches the bloodstream. Arginine then serves as the substrate for nitric oxide synthase (NOS), the enzyme that produces nitric oxide from arginine and oxygen. Nitric oxide diffuses into vascular smooth muscle cells and triggers relaxation of the smooth muscle, dilating blood vessels and increasing blood flow to working tissue.†
The practical effects of elevated nitric oxide are the pump — the increased blood volume in working muscle tissue that creates the feeling of fullness, the visual vascularity from veins becoming more prominent as blood volume rises, and the performance benefits of enhanced oxygen and nutrient delivery to active muscle. At 8g, Bloodline is at the top of the research-validated dose range. Studies documenting the most significant performance and blood flow effects from citrulline generally use 6-8g — doses that most pre-workout products significantly undershoot.†
Mechanism 2 — Osmotic Cellular Hydration: HydroPrime Glycerol — 3,000mg (65% standardized)
HydroPrime is the premium glycerol ingredient from NNB Nutrition, standardized to 65% glycerol content — meaning each 3g dose of HydroPrime delivers approximately 1.95g of active glycerol. This matters because generic glycerol powders commonly used in supplements are often 10-25% glycerol by weight, creating massive dosing discrepancies between products that list the same total weight of glycerol compound on their label. HydroPrime's 65% standardization makes it one of the most concentrated and effective glycerol delivery systems available, and it is engineered to resist the notorious clumping problem that makes generic glycerol powder products unusable after exposure to humidity.†
Glycerol operates through osmosis rather than vasodilation. It draws water into muscle cells by increasing the osmolality of the intracellular environment — essentially hyperhydrating the muscle from the inside out. The result is a different quality of pump than citrulline-driven NO production produces: citrulline creates a vasodilatory pump from increased blood volume; glycerol creates a cellular volumizing pump from increased intracellular water content. Both produce visible muscle fullness and both improve performance — but through different mechanisms, which is why combining them in one formula produces a more complete and longer-lasting result than either alone. The hyperhydration from glycerol also supports endurance by reducing the body's sensitivity to dehydration during prolonged training and improving thermoregulation.†
Mechanism 3 — ACE Inhibition and Vasodilation Maintenance: VasoDrive-AP — 508mg
VasoDrive-AP is a patented ingredient from NovaNutri composed of two specific lactotripeptides derived from casein hydrolysate: Isoleucyl-Prolyl-Proline (IPP) and Valyl-Prolyl-Proline (VPP). These peptides work through a mechanism entirely distinct from the citrulline-NO pathway — they inhibit angiotensin-converting enzyme (ACE), the enzyme responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor. By inhibiting ACE, VasoDrive-AP prevents the vasoconstriction that would otherwise partially counteract the vasodilation produced by elevated nitric oxide.†
Think of it as playing both offense and defense simultaneously: citrulline aggressively drives vasodilation by increasing NO, while VasoDrive-AP defensively blocks the vasoconstrictor that would resist that vasodilation. Clinical research on IPP and VPP peptides has documented improvements in arterial elasticity, endothelial function, and blood flow. The 508mg dose in Bloodline is double what most pump formulas that include VasoDrive-AP use — a characteristic NutraBio move that reflects the brand's refusal to use ingredients at cosmetic doses.†
Mechanism 4 — Endothelial Peptide Signaling: PeptiPump — 200mg
PeptiPump is a novel peptide-based ingredient that supports nitric oxide signaling through endothelial-focused mechanisms — working at the level of the blood vessel wall lining itself rather than through the traditional citrulline-arginine-NO synthesis pathway. PeptiPump supports endothelial nitric oxide synthase (eNOS) activity, the enzyme isoform responsible for the baseline vascular tone that governs how responsive blood vessels are to vasodilatory stimuli. The practical effect is that the vasodilation driven by citrulline and VasoDrive-AP is amplified by a more responsive vascular endothelium — the blood vessels are more capable of relaxing and expanding when they receive the vasodilatory signals the rest of the formula is generating.†
Antioxidant Vasodilation Support: Pine Bark Extract — 200mg
Pine bark extract — standardized for its proanthocyanidin content — is a well-researched antioxidant that supports nitric oxide production and vasodilation through multiple pathways. Proanthocyanidins stimulate eNOS activity, protect NO from oxidative degradation (free radicals destroy NO before it can exert its vasodilatory effects), and support the overall vascular environment that pump-driven blood flow requires. At 200mg, Bloodline includes a full functional dose of pine bark — not a label decoration amount. The antioxidant protection angle is particularly relevant during intense training, when exercise-induced free radical production is elevated and can meaningfully reduce the effective NO concentration driving the pump.†
Absorption Enhancement: AstraGin — 50mg
AstraGin is the patented absorption complex from NuliV Science containing Panax notoginseng and Astragalus membranaceus, standardized for their active ginsenosides and astragalosides. Published research documents AstraGin's ability to increase intestinal amino acid transporter expression — the proteins responsible for actively importing citrulline and other amino acids from the GI tract into the bloodstream. Specifically, AstraGin has been shown to increase citrulline absorption by approximately 45% and arginine absorption by approximately 67% compared to unsupplemented controls. In a formula where citrulline is the primary driver, a 45% improvement in citrulline absorption is the equivalent of adding roughly 3.6g of additional effective citrulline dose without adding any additional citrulline to the formula.†
Frequently Asked Questions About NutraBio Unbound Bloodline
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What is the difference between Bloodline and a regular pump pre-workout?
Most pump pre-workouts run a single mechanism — typically 6-8g of citrulline or citrulline malate, sometimes with a standard glycerol source added. Bloodline covers four distinct physiological mechanisms for pump and blood flow simultaneously: NO production via 8g pure L-Citrulline, osmotic cellular hydration via 3g HydroPrime glycerol, ACE inhibition for sustained vasodilation via 508mg VasoDrive-AP, and endothelial eNOS support via 200mg PeptiPump — with pine bark antioxidants protecting the NO that the formula generates, and AstraGin amplifying citrulline absorption throughout. The practical difference is a pump that is more complete, more visually pronounced, and longer-lasting through the training session than single-mechanism formulas produce at similar price points.† -
How does Bloodline fit into the NutraBio Unbound Series?
The Unbound Series is NutraBio's hardcore performance line — more aggressive ingredient profiles, more cutting-edge compounds, and a more intensity-focused formulation philosophy than the core NutraBio line, while maintaining the same NutraBio manufacturing standards, pharmaceutical-grade GMP facility, full label transparency, and third-party testing that the brand was built on. Bloodline launched in late 2025 as the pump formula of the Unbound Series, designed to be used standalone for stimulant-free sessions or stacked on top of any stimulant pre-workout to add the full pump matrix to a stim-only formula. It pairs naturally within the Unbound line with the high-stimulant pre-workout Unload for athletes who want maximum energy plus maximum pump in the same session.† -
Can I stack Bloodline with my current pre-workout?
Yes — this is specifically how Bloodline is designed to be used. Because it contains zero stimulants, it adds no caffeine, synephrine, or any other CNS compound to whatever pre-workout you already use. The pump matrix in most stimulant pre-workouts — even good ones — is often secondary to the energy and focus stack in terms of ingredient budget. Bloodline adds a complete, fully dosed standalone pump matrix on top of your existing energy and focus. The combination of your stimulant pre-workout's energy layer and Bloodline's pump layer produces a training experience that neither product delivers alone. Stack Bloodline with anything — there are no contraindication concerns from combining it with stimulant products.† -
Who is Unbound Bloodline not for?
Athletes whose primary goal is energy or endurance rather than pump and vascularity — Bloodline has no stimulants and no endurance-specific compounds like beta-alanine or betaine. It is purpose-built for blood flow and muscle fullness. Drug-tested athletes should note that VasoDrive-AP is derived from casein (milk protein) — those with dairy allergies should consult a physician before use. Anyone who wants both the pump and the stimulant layer in a single product should look at a stimulant pre-workout with a strong pump matrix rather than stacking separately.†
How to Take NutraBio Unbound Bloodline
Mix 1 scoop with 14-16oz of cold water and consume 20-30 minutes before training. The larger water volume (14-16oz vs. the 8-10oz typical for most pre-workouts) is recommended because of the glycerol content — glycerol works by pulling water into cells and functions best when adequate systemic hydration is maintained. Continue hydrating during training. Stack with any stimulant pre-workout for combined pump and energy — there are no stimulant contraindications. California Residents: This product can expose you to chemicals including Lead, known to the State of California to cause cancer and birth defects or other reproductive harm. Visit www.P65Warnings.ca.gov/food for more information.†
Why Buy at Get Yok'd
- Real-time inventory across all five Southern California stores
- Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
- Authorized retailer of NutraBio
- One of the best loyalty programs in the supplement industry — earn rewards on every purchase
- Owned and operated by fitness enthusiasts who actually use what we sell
Who Should Not Take NutraBio Unbound Bloodline
- Not for use by persons under 18
- Not for pregnant or nursing women
- VasoDrive-AP is derived from casein (milk) — not suitable for individuals with dairy allergies
- Consult a physician before use if you have cardiovascular conditions or are taking blood pressure medications — VasoDrive-AP has ACE-inhibiting properties that may interact with antihypertensive medications
- Consult a physician before use if taking any prescription medications or have a pre-existing medical condition
- Keep out of reach of children
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.