Hi-Tech Pharmaceuticals - Amp3D

Hi-Tech Pharmaceuticals AMP3D is the brand's flagship extreme high-stimulant pre-workout — the successor to Krank3d and Jack'd Up, built around two innovations that separate it from every other pre-workout in the Hi-Tech lineup: Citrulline Silicate (Nitro-Rx®), Hi-Tech's proprietary NO compound combining citrulline with silicon for sustained arginine elevation and superior NO production, and BEC (S-(2-boronethyl)-L-cysteine HCl), a novel arginase inhibitor that prevents arginase from breaking down arginine before it can be converted to nitric oxide. The result is a formula that saturates the arginine-eNOS-NO pathway from two angles simultaneously — increasing arginine production while blocking its degradation — for maximum muscular vasodilation. On top of the pump architecture: 4,000mg L-Citrulline, Agmatine Silicate, L-Arginine HCl, Beta-Alanine, Glycerol, Taurine, and the 590mg Neurogenix Energizer Blend — Caffeine Anhydrous (~300mg), DMHA (2-Aminoisoheptane), Theobromine, Phenylethylamine HCl, and Yohimbine Extract. 25 servings per container. Start with half a scoop on an empty stomach to assess tolerance. Do not exceed 2 scoops in 24 hours. Not for tested athletes. California Prop 65 Warning applies.†

WARNING: AMP3D is an extreme high-stimulant pre-workout containing DMHA (2-Aminoisoheptane), Caffeine, Phenylethylamine, and Yohimbine. Start with half a scoop regardless of your stimulant experience. This product can raise blood pressure and interfere with medications. Do not combine with any other stimulant products. Not for persons under 18.

Supplement Facts — Hi-Tech Pharmaceuticals AMP3D (Per 1 Scoop / 25 Servings)

NO and Pump Matrix

• L-Citrulline — 4,000mg
• Citrulline Silicate (as Nitro-Rx®) — patented silicon-stabilized citrulline for sustained arginine elevation and enhanced NO production
• L-Arginine HCl — direct eNOS substrate for NO synthesis
• Agmatine Silicate — arginase inhibitor and NON-eNOS vasodilator
• S-(2-boronethyl)-L-cysteine HCl (BEC) — Hi-Tech's novel arginase inhibitor; renders arginase inactive so arginine can't be broken down before reaching NOS enzymes

Cell Volumizing and Hydration Blend

• Beta-Alanine — 3,200mg — clinical carnosine buffering dose for muscular endurance
• Glycerol — osmotic hyperhydration and intracellular cell volumization
• Taurine — cellular hydration, anti-fatigue, and cardiovascular performance support

Neurogenix Energizer Blend — 590mg (Proprietary)

• Caffeine Anhydrous (~300mg) — primary CNS stimulant and adenosine antagonist
• 2-Aminoisoheptane (DMHA) — CNS stimulant with warm euphoric energy and focus; dopamine/norepinephrine releaser
• Theobromine Anhydrous — extended energy duration; mild bronchodilator
• Phenylethylamine HCl (PEA) — rapid-onset mood elevation and catecholamine release
• Yohimbine Extract — alpha-2 adrenergic blockade for fat mobilization and CNS stimulation

• Note: The Neurogenix Energizer Blend is a 590mg proprietary blend — individual stimulant doses within this blend are not disclosed except where noted. Caffeine is confirmed at approximately 300mg based on the Get Yok'd product listing and Hi-Tech documentation.
• 25 servings per container. 1 scoop per serving.
• Start with half a scoop on an empty stomach to assess tolerance before advancing to a full scoop.
• Do not exceed 2 scoops in any 24-hour period.
• Mix 1 scoop in 6-8oz water. Do not take with food.
• Do not take within 6 hours of bedtime.
• Flavors: Blue Razzberry, Fruit Punch, Peach Ring, Rocket Pop, Snowcone, Tutti Frutti, Watermelon, Sour Gummy
• Not for tested athletes — DMHA and Yohimbine are prohibited by WADA and NCAA
• This product can raise blood pressure and interfere with other drugs. Consult a physician before use.
• California Prop 65 Warning applies.

The AMP3D Innovation — Arginase Inhibition: The Problem Every Other NO Pre-Workout Ignores

Nitric oxide supplementation has been a cornerstone of the pre-workout category since the mid-2000s. The standard approach — give the body more arginine or citrulline so it can make more NO — is well-documented and works. But Hi-Tech identified a fundamental flaw in this approach that has gone unaddressed in virtually every competitor's formula: arginase.†

Arginase is the enzyme responsible for degrading arginine in the body. Every molecule of arginine you consume or synthesize from citrulline must run a gauntlet — arginase competes with nitric oxide synthase (NOS) for the same arginine substrate. When arginase wins that competition, arginine is converted to ornithine and urea rather than to nitric oxide. Most NO supplements pour more arginine into a system where arginase is still fully active — you're filling a bucket that has a hole in it. The arginine production increases but so does its degradation. The net increase in NO is limited by the ongoing arginase activity that the formula does nothing to address.†

Hi-Tech's solution is BEC — S-(2-boronethyl)-L-cysteine HCl — a novel arginase inhibitor that bonds directly to arginase enzyme active sites and renders them non-functional. When BEC inactivates arginase, it stops the competing degradation pathway entirely. Now the arginine generated by Citrulline, Citrulline Silicate (Nitro-Rx), Agmatine, and L-Arginine HCl has no competition for reaching NOS enzymes — the full arginine pool is available for NO synthesis. The result is substantially greater NO production from the same arginine input than any formula without arginase inhibition can achieve.†

Nitro-Rx® Citrulline Silicate — What Silicon Does for NO Production

Hi-Tech's Nitro-Rx® is their proprietary form of citrulline bound to silicate — silicon dioxide chemically associated with the citrulline molecule. The silicon component plays a specific role in vascular biology: silicon is heavily concentrated in arterial walls where it crosslinks with glycosaminoglycans (structural proteins in the arterial wall matrix) to maintain arterial elasticity and structural integrity. With age and oxidative stress, arterial silicon content decreases and arterial stiffness increases — a phenomenon associated with reduced exercise capacity and impaired circulation. Citrulline Silicate simultaneously provides the standard citrulline-derived arginine for eNOS-mediated NO production AND delivers silicon directly to vascular tissue, supporting the structural health of the blood vessels that NO is relaxing. The sustained arginine elevation documented for this compound class (up to 6 hours versus standard citrulline's 2-3 hour peak) produces longer-lasting NO production and extended pump duration than citrulline alone provides.†

The Neurogenix Energizer Blend — Five Stimulants, Four Mechanisms

The 590mg Neurogenix Energizer Blend is where AMP3D earns its high-stim reputation. Five compounds cover four distinct stimulant and catecholaminergic mechanisms simultaneously — the combination produces an energy and focus experience that experienced high-stim pre-workout users consistently describe as qualitatively different from caffeine-only or caffeine-plus-one-additional-stimulant products.†

Caffeine Anhydrous (~300mg) provides the adenosine antagonism and immediate CNS arousal that forms the baseline of any stimulant pre-workout. At approximately 300mg it's a strong but not extreme caffeine dose — meaningful when combined with the other four stimulant compounds in the blend. DMHA (2-Aminoisoheptane) — also known as 2-amino-5-methylheptane or octodrine — is an aliphatic amine stimulant that produces CNS stimulation, bronchodilation, and thermogenesis through adrenergic and monoamine reuptake inhibition mechanisms. DMHA is structurally related to DMAA but with a slightly different carbon chain — it produces a warm, euphoric, motivating energy wave that experienced DMHA users consistently distinguish from caffeine's sharp alertness. It is the ingredient responsible for AMP3D's comparison to the original Jack3d's most distinctive characteristics. DMHA is prohibited by WADA.†

Theobromine Anhydrous extends the total energy duration — its 6-10 hour half-life creates a secondary energy wave as caffeine's 3-5 hour duration begins to taper, smoothing the overall energy curve and preventing the hard crash. Phenylethylamine HCl (PEA) provides the rapid-onset mood elevation and dopamine/norepinephrine release that produces the euphoric, motivated pre-workout state — PEA's own half-life is short, but combined with the MAO enzyme modulation from Theobromine and DMHA, it contributes a meaningful mood and motivational dimension. Yohimbine Extract completes the blend with alpha-2 adrenergic receptor blockade — removing the inhibitory brake on lipolysis in fat cells while adding additional CNS stimulant and mood-elevating effects through the yohimbe alkaloid mechanism. The five compounds together produce the hardest-hitting, most multidimensional stimulant experience in Hi-Tech's current pre-workout lineup.†

AMP3D in the Hi-Tech Pre-Workout Lineup

Hi-Tech operates the largest pre-workout portfolio in the specialty supplement channel — Mesomorph (their benchmark high-stim formula with ephedra), Jack3d (the classic lightweight DMHA powder), Wicked (another DMHA entry), Ultimate Orange (the nostalgic brand), and now AMP3D at the top of the lineup. Hi-Tech positions AMP3D as the "Cadillac" of their pre-workout stable — the formula that combines the most advanced pump architecture (Nitro-Rx Citrulline Silicate, BEC arginase inhibition, Agmatine Silicate, L-Arginine HCl) with the most sophisticated stimulant complex in one product. Where Mesomorph relies on ephedra alkaloids for its primary stim effect, AMP3D uses DMHA + caffeine + PEA + Theobromine + Yohimbine — a newer, legal-in-all-states stimulant architecture that delivers comparable energy intensity through different mechanisms.†

Frequently Asked Questions

1. What is DMHA and why is it in AMP3D?
   DMHA (2-Aminoisoheptane / 2-amino-5-methylheptane) is an aliphatic amine stimulant derived from the Juglans Regia (walnut) plant. It produces CNS stimulation, bronchodilation, mood elevation, and thermogenesis through adrenergic mechanisms and monoamine reuptake inhibition. Experienced users of original Jack3d (which contained DMAA) frequently describe DMHA as producing a similar warm, euphoric, focused energy wave — a more gradual, sustained stimulant experience than caffeine's sharp onset. DMHA is currently legal in the United States as a dietary supplement ingredient. It is prohibited by WADA and the NCAA. Not for athletes in any tested sport.†
2. Why does the formula use both Citrulline AND Citrulline Silicate (Nitro-Rx)?
   The two forms address different aspects of the arginine-eNOS-NO pathway. Standard L-Citrulline at 4,000mg provides rapid-onset arginine generation through the kidney's citrulline-to-arginine conversion pathway — a well-documented and fast-acting pump mechanism. Citrulline Silicate (Nitro-Rx) provides slower, more sustained arginine elevation lasting up to 6 hours, along with silicon delivery to vascular tissue. Using both forms together provides immediate onset (standard citrulline) with extended duration (citrulline silicate), creating a pump that starts quickly and lasts through the entire session.†
3. How does AMP3D compare to Mesomorph?
   Mesomorph is Hi-Tech's ephedra-alkaloid-containing pre-workout — its primary stimulant mechanism is ephedrine from Ma Huang extract, which is the most potent legal stimulant available in dietary supplements but requires purchase from a specialty retailer. AMP3D uses DMHA instead of ephedra as its primary high-stim compound — also a powerful stimulant, legal in all 50 states without any purchase restriction, with a different energy character (warmer and more euphoric versus ephedra's harder adrenergic profile). The pump matrix in AMP3D (BEC arginase inhibition + Nitro-Rx Citrulline Silicate) is more advanced than Mesomorph's. AMP3D is Hi-Tech's most technically sophisticated pre-workout; Mesomorph has the longest track record.†
4. Is AMP3D appropriate for tested athletes?
   No. AMP3D contains DMHA (2-Aminoisoheptane) and Yohimbine — both prohibited by WADA and NCAA. Athletes in any tested sport must not use this product. The pump compounds (Citrulline, Citrulline Silicate, Agmatine, BEC, Beta-Alanine) are all permitted, but the stimulant blend makes the entire formula non-compliant for tested environments.†

How to Take Hi-Tech Pharmaceuticals AMP3D

Start with half a scoop mixed in 6-8oz of water on an empty stomach to assess tolerance — this is mandatory for all users regardless of stimulant experience. DMHA and PEA combined with Caffeine and Yohimbine produce a total stimulant load that is significantly stronger than most standard pre-workouts. Once tolerance is established, advance to 1 full scoop. Do not exceed 2 scoops in any 24-hour period. Do not take with food — empty stomach absorption is recommended by Hi-Tech. Do not take within 6 hours of bedtime — DMHA's extended effects can persist significantly longer than caffeine alone. Do not combine with any other stimulant-containing products, caffeine, energy drinks, or fat burners. This product can raise blood pressure and interfere with medications — consult a physician before use. Not for persons under 18. Not for pregnant or nursing women. Not for tested athletes. California Prop 65 Warning applies.†

Why Buy at Get Yok'd

• Real-time inventory across all five Southern California stores
• Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
• Authorized Hi-Tech Pharmaceuticals retailer — one of a limited number of authorized specialty retailers for the full Hi-Tech pre-workout lineup including Mesomorph, Jack3d, and AMP3D
• Staff who can walk you through the Hi-Tech pre-workout family and help you find the right formula for your tolerance and experience level
• One of the best loyalty programs in the supplement industry — earn rewards on every purchase

Who Should Not Take AMP3D

• Not for persons under 18 years of age
• Not for pregnant or nursing women
• Not for individuals with cardiovascular conditions, high blood pressure, or heart arrhythmia — the combined stimulant load from Caffeine, DMHA, PEA, and Yohimbine is extreme
• Not for individuals with anxiety disorders — DMHA and PEA can powerfully amplify anxiety in susceptible individuals
• Not for individuals with thyroid conditions without physician clearance
• Not for individuals on MAO inhibitors, antidepressants, or psychiatric medications — PEA compounds interact with MAO enzyme systems and serotonergic medications
• Not for tested athletes — contains DMHA and Yohimbine, both prohibited by WADA and NCAA
• Do not combine with any other stimulants, caffeinated products, or fat burners
• Do not use within 6 hours of bedtime
• This product can raise blood pressure and interfere with prescription medications — consult a physician before use
• Discontinue use immediately if you experience rapid heartbeat, severe headache, dizziness, or shortness of breath
• Discontinue use 2 weeks before any scheduled surgery
• California Prop 65 Warning applies.
• Keep out of reach of children.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.