Hi-Tech Pharmaceuticals Berberine features 250mg of Nexrutine® XS Berberine per tablet — a 97% pure standardized extract from Phellodendron amurense bark and stems, equivalent to 12.5g of dried plant material per serving. What separates this from standard berberine products is bioavailability: Hi-Tech's pharmacokinetic studies show Nexrutine® XS improves berberine absorption by over 1,000% compared to standard berberine, extending retention time from 30–45 minutes to over 10 hours.†
Hi-Tech Berberine — What's Inside Each Tablet
- Nexrutine® XS Berberine Cyclosome — 250mg, Phellodendron amurense (stem/bark), standardized to 97% berberine, equivalent to 12.5g of dried bark and stems
- Sodium Caprate (C10) — a medium-chain triglyceride included to further promote optimal absorption and support gastrointestinal comfort during berberine supplementation
- Cyclosome® Delivery — phosphatidylcholine and HPBCD complex for enhanced bioavailability
- 120 tablets per container — 2 tablets per serving
Frequently Asked Questions About Hi-Tech Berberine
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What is berberine and where does it come from?
Berberine is a naturally occurring alkaloid compound found in several plants including barberry, tree turmeric, goldenseal, and Phellodendron amurense. It has been used in traditional Ayurvedic and Chinese medicine for centuries. Modern research has focused on berberine's role in metabolic health, cardiovascular support, gut health, and weight management as part of a healthy lifestyle.† -
Why is standard berberine considered poorly bioavailable?
Raw berberine extract has inherently poor oral bioavailability — it is rapidly metabolized and eliminated before meaningful levels can accumulate in circulation. Standard berberine supplements have a retention time of only 30–45 minutes in the body. Hi-Tech's Nexrutine® XS addresses this directly by using Cyclosome® Technology to extend berberine's retention time to over 10 hours and increasing total absorption by over 1,000% compared to standard products.† -
How does berberine work in the body?
Berberine operates by influencing key metabolic regulators including AMPK, PKC, and SIRT1 — cellular energy and metabolic homeostasis controllers that play a role in how the body manages carbohydrate and lipid metabolism. This mechanism is why berberine has attracted significant research interest across multiple areas of metabolic health support.† -
Who is berberine most commonly used by?
Berberine has grown significantly in popularity among athletes using prohormones who want cardiovascular and metabolic support on cycle, individuals focused on general metabolic health as part of a calorie-controlled diet, and anyone looking for a well-researched botanical for long-term wellness support. It stacks well with Hi-Tech's Citrus Bergamot for a more comprehensive cardiovascular support stack.† -
When should I take Hi-Tech Berberine?
Take with or shortly after a meal — berberine works best when taken in relation to food intake. The recommended protocol is 2 tablets taken 2–3 times daily with meals. Spreading doses throughout the day maintains more consistent circulating levels given berberine's metabolism profile.†
How to Take Hi-Tech Berberine
Take 2 tablets 2–3 times daily with meals, or as directed by a physician. Do not exceed the recommended dose. Store in a cool dry place after opening.
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Who Should Not Take Hi-Tech Berberine
- Consult a physician before use if pregnant, nursing, taking prescription medications, or have a medical condition
- This product is not intended for individuals with impaired glucose metabolism — consult your physician before use if you have diabetes or a related condition
- Do not exceed the recommended dose
- Keep out of reach of children
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.