MuscleSport - Liver & Kidney - 60 Capsules

MuscleSport Liver & Kidney Revolution™ is a four-ingredient liver and kidney support formula built around the most clinically researched hepatoprotective and detoxification compounds available: Milk Thistle Extract (Silybum marianum, standardized for Silymarin), N-Acetyl Cysteine (NAC), Turmeric Extract, and Artichoke Extract. Designed to support the over 500 physiological functions that the liver and kidneys perform daily — from Phase I and Phase II detoxification to bile production, antioxidant defense, and cellular regeneration. 60 capsules per container — 30 two-capsule servings. Take 2 capsules upon waking. Part of MuscleSport's Wellness Series. Stacks with Adrenal Revolution, Joint Revolution, and Multi Vita Revolution for comprehensive organ health support. California Prop 65 Warning applies.†

Supplement Facts — MuscleSport Liver & Kidney Revolution (Per 2 Capsules / 30 Servings)

• Milk Thistle Extract (Silybum marianum, standardized for Silymarin)
• N-Acetyl Cysteine (NAC)
• Turmeric Extract
• Artichoke Extract

• Individual ingredient doses are disclosed on the product label
• 60 capsules per container — 30 two-capsule servings
• Take 2 capsules upon waking
• Stacks with: Adrenal Revolution, Joint Revolution, Multi Vita Revolution
• California Prop 65 Warning applies.

Why Liver and Kidney Health Matters for Active Individuals

The liver performs over 500 distinct physiological functions — the kidneys perform hundreds more. Together they are the body's primary detoxification and filtration infrastructure: the liver processes every compound ingested or produced metabolically (food, alcohol, medications, supplements, metabolic waste products) through Phase I cytochrome P450 oxidation and Phase II conjugation reactions before passing the processed compounds to the kidneys for excretion. The kidneys then filter approximately 200 liters of blood per day, removing waste products, balancing electrolytes, and regulating fluid balance.†

For active individuals — particularly those running supplement stacks, using prohormones or anabolic compounds, consuming protein at high levels, or training at high volumes — the demand on both organs is significantly elevated above sedentary baseline. High protein intake increases nitrogen waste processing demands on the kidneys. Prohormone cycles increase hepatic processing demands through first-pass metabolism of the prohormone compounds. Training-induced inflammation and muscle breakdown produce metabolic byproducts that require liver and kidney processing. Even a comprehensive supplement stack — pre-workouts, fat burners, vitamins, creatine, protein — increases the cumulative processing load on these organs. Supporting the liver and kidneys through this elevated demand with targeted botanical and amino acid compounds is one of the most practical and underutilized elements of a complete sports nutrition program.†

The Four Ingredients — What Each One Does

Milk Thistle Extract (Silybum marianum / Silymarin) — The Liver's Most Researched Protector

Milk Thistle has been used medicinally for over 2,000 years and has accumulated more peer-reviewed research on hepatoprotective activity than any other botanical liver support compound. The active component is Silymarin — a flavonoid complex consisting primarily of silybin, silychristin, and silydianin — standardized from the seeds of Silybum marianum. MuscleSport cites four published peer-reviewed studies on Milk Thistle's efficacy in the product's reference list, including a 2012 JAMA randomized controlled trial, a 2002 meta-analysis in the American Journal of Medicine, and a 2018 PRISMA meta-analysis of randomized controlled trials for non-alcoholic fatty liver disease treatment.†

Silymarin's hepatoprotective mechanisms are well-established and multifactorial. First, it acts as a competitive inhibitor at hepatocyte membrane receptor sites, blocking the cellular uptake of hepatotoxic compounds — including alcohol metabolites, environmental toxins, and pharmaceutical compounds — before they can enter and damage liver cells. Second, Silymarin is a potent antioxidant specifically within hepatic tissue, neutralizing the reactive oxygen species produced during Phase I cytochrome P450 oxidation reactions — the free radical byproducts that, if unchecked, oxidize hepatocyte membranes and mitochondria. Third, Silymarin stimulates ribosomal RNA synthesis in hepatocytes, directly accelerating liver cell regeneration — replacing damaged cells with functional new hepatocytes. Fourth, Silymarin modulates inflammatory cytokine signaling in the liver, reducing the chronic hepatic inflammation that accompanies sustained organ stress. The breadth of these overlapping mechanisms is what makes Milk Thistle the foundation of virtually every credible liver support formula.†

N-Acetyl Cysteine (NAC) — Glutathione Synthesis and Detoxification Support

N-Acetyl Cysteine is the acetylated, more bioavailable form of the amino acid cysteine — and its primary hepatic relevance is as the rate-limiting precursor to glutathione synthesis. Glutathione is the most abundant intracellular antioxidant in hepatocytes and the primary non-enzymatic compound in Phase II liver detoxification — the conjugation reactions that make fat-soluble toxins water-soluble and excretable. Without adequate glutathione, the liver's ability to complete Phase II detoxification is severely compromised.†

MuscleSport references the landmark 1979 BMJ study (Prescott et al.) establishing that intravenous NAC is the pharmaceutical standard of care for acetaminophen overdose — selected specifically because NAC rapidly restores liver glutathione stores before acetaminophen's toxic metabolite NAPQI can cause irreversible hepatocyte destruction. This citation is the most direct demonstration available of NAC's critical role in liver glutathione maintenance — NAC is literally the drug that saves livers. In a supplemental context at oral doses, NAC supports the ongoing daily maintenance of glutathione levels during periods of elevated liver processing demand — whether from prohormone cycles, high-volume training, alcohol consumption, or simply a comprehensive supplement protocol.†

Turmeric Extract (Curcumin) — Anti-Inflammatory and Antioxidant Support

Turmeric root extract (Curcuma longa, standardized for Curcuminoids — primarily Curcumin) addresses liver and kidney health through potent anti-inflammatory and antioxidant mechanisms. Curcumin is one of the most studied natural anti-inflammatory compounds available, inhibiting NF-κB (the master inflammatory transcription factor), COX-1 and COX-2 enzymes, and multiple inflammatory cytokines. In the liver, chronic inflammation is a significant driver of hepatic fibrosis and long-term organ damage — Curcumin's anti-inflammatory activity helps maintain the hepatic inflammatory environment at healthy levels during periods of elevated organ stress.†

Curcumin also has direct antioxidant activity in kidney tissue, where oxidative stress from filtered metabolic waste products and nephrotoxic compounds is an ongoing challenge. Research on Curcumin specifically documents protective effects on renal tubular cells from oxidative damage, supporting kidney function during high-protein and high-supplement dietary periods. Curcumin's documented challenge is bioavailability — the compound is rapidly metabolized in the intestine and liver, limiting systemic availability from standard extracts. The inclusion of Turmeric Extract in MuscleSport's formula alongside the other active ingredients is intended to provide meaningful Curcumin activity for liver and kidney support.†

Artichoke Extract (Cynara scolymus) — Bile Flow and Liver Regeneration Support

Artichoke Leaf Extract (Cynara scolymus) is a choleretic botanical — it stimulates bile production and bile flow from the liver and gallbladder into the intestinal tract. Bile is essential for fat digestion and the excretion of fat-soluble toxins that the liver has processed through Phase I and Phase II reactions. When bile flow is sluggish, these processed fat-soluble toxins accumulate in the biliary system rather than being efficiently excreted — Artichoke Extract's choleretic activity supports their clearance. Artichoke Extract also contains Cynarin and Luteolin — compounds with documented antioxidant, hepatoprotective, and lipid-lowering properties. Research has documented Artichoke Extract's hepatoprotective effects in non-alcoholic fatty liver disease, improvements in liver enzyme levels (ALT, AST) in individuals with elevated liver enzymes, and support for healthy cholesterol metabolism through bile acid synthesis effects.†

The Clinical Literature Behind the Formula

MuscleSport references peer-reviewed clinical research for both core active compounds in the product description — demonstrating that the formula is built on documented evidence rather than traditional use alone. The cited studies cover Milk Thistle's effects in chronic hepatitis C (2012 JAMA randomized controlled trial — Fried et al.), systematic review and meta-analysis of Milk Thistle for liver disease (2002 American Journal of Medicine — Jacobs et al.), meta-analysis of Silymarin for non-alcoholic fatty liver disease (2018 Phytotherapy Research — Abenavoli et al.), and the foundational 1979 BMJ study establishing NAC as standard of care for acetaminophen-induced liver failure (Prescott et al.). This is not typical for wellness supplements — most liver support products include no research citations. The inclusion of JAMA-published research specifically signals formula credibility beyond marketing claims.†

MuscleSport Wellness Series — Where Liver & Kidney Fits

MuscleSport's Wellness Series is their non-performance general health product line, designed to support the underlying physiological systems that athletic performance depends on. Liver & Kidney Revolution is positioned alongside Adrenal Revolution (cortisol and stress management), Joint Revolution (joint and connective tissue support), and Multi Vita Revolution (comprehensive daily multivitamin) as the organ health pillar of a complete wellness stack. For Get Yok'd customers who run prohormone cycles, heavy supplement protocols, or year-round high-volume training, Liver & Kidney Revolution provides the foundational organ support that dedicated training programs require.†

Frequently Asked Questions

1. Should I take Liver & Kidney Revolution on cycle or post-cycle?
   Both — and ideally throughout. During a prohormone or supplement cycle, the liver is processing the first-pass metabolism of prohormone compounds, creating elevated oxidative stress and detoxification demand. Milk Thistle and NAC provide real-time hepatoprotection during this period. Post-cycle, Silymarin's hepatocyte regeneration mechanism and NAC's glutathione restoration support liver recovery as the compound load clears. For most athletes, continuous use throughout and after a cycle provides the most comprehensive coverage.†
2. Why take it upon waking specifically?
   Taking Liver & Kidney Revolution on an empty stomach in the morning maximizes absorption of the active botanical compounds. Milk Thistle and NAC both absorb more efficiently without competition from dietary macronutrients — particularly dietary fats that can compete with lipophilic plant compounds for absorption pathways. Morning dosing also ensures the formula is active during the early part of the day when liver detoxification activity (Phase I and II reactions) is typically highest based on circadian rhythm patterns of liver enzyme activity.†
3. How does Liver & Kidney Revolution compare to NutraKey Liver Optima?
   Both products address liver health through Milk Thistle and NAC as core compounds. NutraKey Liver Optima adds Acetyl-L-Carnitine, L-Glutathione (free form), and L-Methionine — providing direct glutathione and methylation pathway support alongside the botanical base. MuscleSport Liver & Kidney adds Turmeric Extract and Artichoke Extract — providing anti-inflammatory, choleretic (bile flow), and kidney-specific support that Liver Optima doesn't include. MuscleSport's formula addresses liver + kidney simultaneously with an anti-inflammatory and bile flow dimension; NutraKey's formula is liver-focused with direct glutathione precursor support.†
4. Can Liver & Kidney Revolution be used as a daily supplement long-term?
   Yes — all four ingredients in Liver & Kidney Revolution have well-established long-term safety profiles at typical supplement doses. Milk Thistle has been safely used for centuries and in clinical trials running 24+ months. NAC, Turmeric Extract, and Artichoke Extract are all naturally occurring compounds with excellent safety records for continuous daily use. Unlike NutraBio Diuretic (which contains Uva Ursi requiring cycling due to its Arbutin content), Liver & Kidney Revolution has no ingredient-specific cycle requirement.†

How to Take MuscleSport Liver & Kidney Revolution

Take 2 capsules upon waking, preferably on an empty stomach. For athletes on prohormone cycles or heavy supplement protocols, consistent daily use throughout the cycle and for several weeks post-cycle provides the most comprehensive organ support. Can be stacked with MuscleSport Adrenal Revolution, Joint Revolution, and Multi Vita Revolution for comprehensive wellness coverage. Consult a physician before use if taking any prescription medications — Milk Thistle has documented effects on cytochrome P450 enzymes involved in pharmaceutical metabolism. Not for persons under 18. Not for pregnant or nursing women. Discontinue use if you experience any adverse reactions. Store in a cool, dry place. California Prop 65 Warning applies.†

Why Buy at Get Yok'd

• Real-time inventory across all five Southern California stores
• Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
• Authorized MuscleSport retailer — carrying the full Wellness Series lineup
• Staff who can help you build the right on-cycle organ support stack in person
• One of the best loyalty programs in the supplement industry — earn rewards on every purchase

Who Should Exercise Caution with Liver & Kidney Revolution

• Not for persons under 18 years of age
• Not for pregnant or nursing women
• Individuals taking blood thinners (Warfarin/Coumadin) should consult a physician — Milk Thistle affects CYP2C9 liver enzymes involved in Warfarin metabolism
• Individuals taking prescription medications should consult a physician — Milk Thistle affects cytochrome P450 enzymes (particularly CYP3A4 and CYP2C9) that metabolize many pharmaceuticals
• Individuals with known allergies to plants in the Asteraceae/Compositae family (ragweed, daisies, marigolds) may be sensitive to Milk Thistle and Artichoke
• Individuals with a history of gallstones should consult a physician before using Artichoke Extract — its choleretic (bile-stimulating) activity may trigger gallbladder discomfort
• Individuals with hormone-sensitive conditions should consult a physician — Milk Thistle has mild estrogenic activity at high doses
• Discontinue use and consult a physician if you experience any adverse reactions
• California Prop 65 Warning applies.
• Keep out of reach of children.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.