Revive MD Creatine + HMB is a five-ingredient performance formula that addresses the most overlooked limitation of standard creatine supplementation: the transporter. Most creatine supplements rely on a single pathway to reach your muscles, and research suggests that pathway becomes less efficient over time. Revive MD's solution is GAA (Guanidinoacetic Acid) — a compound that uses a different route into muscle tissue and converts to creatine once inside the cell. A published human clinical trial found that combining GAA with creatine was associated with 16.9% greater muscle creatine levels compared to 2.0% with creatine alone. Per scoop: 5g Creatine Monohydrate, 2g GAA, 3g HMB (Calcium Beta-Hydroxy Beta-Methylbutyrate), 1.5g Betaine Anhydrous, and 1g Taurine. Fully disclosed label, no proprietary blends. Every ingredient at its exact dose. Manufactured in a GMP-certified facility and third-party tested every batch. Informed Sport certified — tested for 270+ banned substances. 30 servings. $49.99. Flavors: Lemon Lime and Unflavored. Lemon Lime uses fermented Reb M (ONOSWEET) and monk fruit extract — zero artificial sweeteners, zero calories, non-glycemic. Safe for tested athletes.†
Supplement Facts — Revive MD Creatine + HMB (Per 1 Scoop / 30 Servings)
Creatine Monohydrate — 5,000mg (5g)
Guanidinoacetic Acid (GAA) — 2,000mg (2g)
HMB (Calcium Beta-Hydroxy Beta-Methylbutyrate) — 3,000mg (3g)
Betaine Anhydrous — 1,500mg (1.5g)
Taurine — 1,000mg (1g)
Fully disclosed label. No proprietary blends. Every ingredient at its exact dose.
Zero artificial sweeteners (Lemon Lime flavor — fermented Reb M + Monk Fruit)
Zero calories. Non-glycemic.
Unflavored version also available
Informed Sport certified — tested for 270+ WADA-prohibited substances
Manufactured in a GMP-certified facility and third-party tested every batch.
30 servings per container. $49.99.
Safe for tested athletes — Informed Sport certification
Revive MD — The Brand Behind the Formula
Revive MD was founded by Matt Jansen and Dr. Domenic Iacovone with a specific mandate: bring the clinical rigor of physician-designed supplementation to the sports nutrition category. Every Revive MD formula is built around peer-reviewed research, full ingredient transparency, and third-party testing standards that most performance supplement brands don't meet. The brand's catalog spans organ support (Kidney Support, Liver Support, Omega-3), daily wellness (Magnesium Glycinate, comprehensive vitamins), hormone health, and performance — all designed by the same physician-oversight process. Revive MD Creatine + HMB is backed by Dr. Adeel Khan, MD — a physician collaborator for the performance line whose clinical background informs the ingredient selection and dosing.†
The Problem With Standard Creatine — And What GAA Solves
Most creatine supplements rely on a single pathway to reach your muscles, and research suggests that pathway becomes less efficient over time. The pathway in question is the creatine transporter (SLC6A8) — the protein that shuttles creatine from the bloodstream into muscle cells. This transporter becomes downregulated with chronic creatine supplementation, which is the primary reason many experienced creatine users report a plateau in their response. They are still taking creatine. The creatine is still being absorbed from the GI tract. But the transporter efficiency has declined, and less of the circulating creatine is making it into the muscle cell where it needs to be.†
GAA (Guanidinoacetic Acid) addresses this problem by using a different transporter. GAA uses a different route into muscle tissue and converts to creatine once inside the cell. GAA is the direct biosynthetic precursor to creatine — the compound the liver and kidneys produce as the intermediary step in the body's own creatine synthesis. When GAA is taken orally, it absorbs through the GABA transporter pathway (not the creatine transporter), enters muscle cells, and is then methylated to creatine inside the cell by the HNMT and GAMT enzymes. Because it uses a different entry pathway, GAA bypasses the downregulation that limits creatine transporter efficiency — meaning it continues to deliver intracellular creatine even when the creatine transporter is suppressed. A published human clinical trial found that combining GAA with creatine was associated with 16.9% greater muscle creatine levels compared to 2.0% with creatine alone.†
The 16.9% versus 2.0% comparison is striking — it reflects the magnitude of the transporter limitation in creatine-experienced athletes and the degree to which GAA's alternate pathway overcomes it. For an athlete who has been supplementing creatine for months or years and has noticed diminishing response, the addition of 2g GAA to the standard 5g creatine dose may produce a more meaningful improvement in muscle creatine levels than simply increasing the creatine dose would.†
HMB — The Most Underutilized Anti-Catabolic Compound
HMB (Beta-Hydroxy Beta-Methylbutyrate) is the active metabolite of leucine — the same amino acid that serves as the primary mTOR activator in muscle protein synthesis. Approximately 5% of dietary leucine is converted to HMB in the body; supplemental HMB provides a direct route to the compound at doses not achievable through food alone. HMB is a naturally occurring leucine metabolite. The International Society of Sports Nutrition (ISSN) position stand references 3g per day in its review of HMB research, and this formula delivers that full amount in a single serving.†
HMB's documented mechanisms are primarily anti-catabolic rather than anabolic — it inhibits the ubiquitin-proteasome proteolytic pathway, the primary cellular machinery responsible for muscle protein breakdown, reducing the rate of muscle protein degradation under exercise, caloric deficit, and recovery stress. HMB also activates mTOR for protein synthesis and has documented effects on satellite cell activation for muscle repair. The net result is reduced muscle damage from intense training, faster recovery, and preservation of lean mass during cutting phases.†
HMB research has been conducted extensively in three populations where it performs most consistently: untrained beginners (whose high muscle damage response to novel training stimuli responds well to HMB's anti-catabolic protection), older adults (where muscle preservation from sarcopenia is clinically significant), and experienced athletes during periods of high training stress, caloric deficit, or recovery from injury. At the 3g ISSN-referenced dose, Revive MD Creatine + HMB is delivering HMB at the level the research literature identifies as effective.†
The Supporting Compounds — Betaine and Taurine
Betaine is an osmolyte and methyl donor naturally found in foods such as beets and spinach. At 1.5g in this formula, Betaine provides meaningful osmotic cellular hydration support — drawing water into muscle cells alongside the creatine for intracellular volumization — alongside its methyl donor role in creatine synthesis itself. Betaine is a cofactor in the methylation reaction that converts homocysteine to methionine, which is the same pathway through which creatine is synthesized. In a formula specifically designed to maximize muscle creatine levels, including Betaine as a methyl donor is mechanistically coherent — it supports the cell's own creatine synthesis capacity alongside the exogenous creatine and GAA being supplemented.†
Taurine is a conditionally essential amino acid also found naturally in the body. At 1g, Taurine provides a fourth osmolyte for cellular hydration alongside creatine's own water-binding, Betaine's osmotic activity, and GAA's intracellular conversion. Taurine also supports cardiovascular function and has anti-fatigue properties documented in multiple research contexts — a clean supporting compound for a performance formula with no additional complexity.†
Informed Sport Certification — Why It Matters for Tested Athletes
Informed Sport is one of the most rigorous third-party supplement testing certifications available — every batch of a certified product is tested for 270+ substances on the WADA prohibited list before release for sale. For tested athletes in any sport, Informed Sport certification is the closest available guarantee that a supplement will not produce an inadvertent positive drug test. Revive MD Creatine + HMB carries Informed Sport certification — the same certification Get Yok'd recommends for all competitive athletes when discussing supplement safety. Combined with GMP manufacturing and the fully transparent label, this is one of the cleanest performance supplements available for athlete use.†
The Natural Sweetener System — Fermented Reb M + Monk Fruit
The Lemon Lime flavor uses fermented Reb M (ONOSWEET) and monk fruit extract. Zero artificial sweeteners, zero calories, non-glycemic. Fermented Reb M delivers significantly less aftertaste than conventional Reb A stevia. The distinction between Reb M and conventional Reb A (the most common stevia extract) is taste quality. Conventional Reb A is associated with the bitter, lingering stevia aftertaste that many users dislike. Reb M (rebaudioside M) is a minor steviol glycoside present in much smaller quantities in the stevia leaf than Reb A — it has a cleaner, sweeter taste profile with significantly less bitterness and aftertaste. Fermented Reb M (produced through yeast fermentation rather than leaf extraction) achieves the same clean taste without requiring large quantities of stevia leaf, resulting in a more consistent, less bitter sweetening experience. For users who prefer natural sweeteners but have been deterred by standard stevia's aftertaste, fermented Reb M represents a meaningful quality upgrade.†
Frequently Asked Questions
What is GAA and why doesn't standard creatine include it?
GAA (Guanidinoacetic Acid) is a compound that uses a different route into muscle tissue than creatine and converts to creatine once inside the cell. Standard creatine uses the SLC6A8 creatine transporter — a pathway that becomes downregulated with chronic supplementation, reducing creatine uptake efficiency over time. GAA uses the GABA transporter pathway, bypassing this downregulation and continuing to deliver intracellular creatine effectively. GAA is a newer and more expensive ingredient than creatine monohydrate, which is why most creatine supplements don't include it. A published human clinical trial found combining GAA with creatine was associated with 16.9% greater muscle creatine levels compared to 2.0% with creatine alone — a clinically meaningful difference.†How is HMB different from taking extra leucine or BCAAs?
HMB is the specific metabolite of leucine responsible for most of its anti-catabolic effects — approximately 5% of leucine converts to HMB in the body. To achieve 3g of HMB from leucine alone would require consuming approximately 60g of leucine daily, which is physiologically impractical and unnecessary. Supplemental HMB delivers the active anti-catabolic compound directly at the ISSN-referenced 3g effective dose without requiring impractical leucine quantities. BCAAs provide muscle protein synthesis signaling and substrate — HMB specifically inhibits muscle protein breakdown. They address complementary rather than identical biological processes.†Can Revive MD Creatine + HMB be taken alongside other supplements?
Yes — the five ingredients (Creatine Monohydrate, GAA, HMB, Betaine, Taurine) are all non-stimulant compounds with no known interactions with standard supplement categories. It stacks cleanly with protein powders, pre-workouts, fat burners, and any other product. Users who already take standalone creatine should reduce or eliminate that separate supplement when adding Creatine + HMB to avoid excessive daily creatine intake — the 5g in this formula plus a standalone creatine supplement would exceed standard daily dosing.†Is Revive MD Creatine + HMB appropriate for tested athletes?
Yes — with one of the highest levels of assurance available. Revive MD Creatine + HMB is Informed Sport certified and third-party tested every batch for 270+ WADA-prohibited substances. Creatine Monohydrate, GAA, HMB, Betaine Anhydrous, and Taurine are all permitted by WADA and NCAA. The Informed Sport certification and batch testing provide the documentation that tested athletes require for confidence in supplement safety compliance.†
How to Take Revive MD Creatine + HMB
Mix 1 scoop in 8-12oz of water daily. Can be taken at any time of day — before training, after training, or at any other consistent time. GAA note: GAA supplementation increases the body's methylation demand — consistent daily intake of B vitamins (particularly B12, B6, and folate) is recommended alongside GAA supplementation to support the methylation reactions involved in GAA's conversion to creatine. A comprehensive multivitamin taken daily satisfies this requirement. Take consistently every day including rest days — creatine and GAA's muscle creatine-building effect is cumulative and depends on consistent daily dosing. Safe for continuous long-term use. Not for pregnant or nursing women without physician clearance. Consult a physician before use if you have kidney disease.†
Why Buy at Get Yok'd
Real-time inventory across all five Southern California stores
Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
Authorized Revive MD retailer — carrying Creatine + HMB alongside Revive MD's organ support and wellness lineup
Staff who can help you incorporate Revive MD Creatine + HMB into a complete performance and recovery stack in person
One of the best loyalty programs in the supplement industry — earn rewards on every purchase
Who Should Exercise Caution with Creatine + HMB
Individuals with kidney disease or renal impairment should consult a physician — creatine and GAA metabolism both increase renal nitrogen processing
GAA increases methylation demand — daily B-vitamin intake (B12, B6, folate) is recommended alongside GAA supplementation to prevent homocysteine accumulation from the increased methylation activity
Not for pregnant or nursing women without physician clearance
Not for persons under 18 without physician guidance
Individuals with homocystinuria (a rare metabolic disorder affecting homocysteine metabolism) should not use GAA-containing products without physician supervision
Consult a physician before use if taking any prescription medications
Keep out of reach of children.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.