Hi-Tech Pharmaceuticals Estrogenex 2nd Generation is a natural testosterone liberator and estrogen blocker built around a 600mg proprietary blend with Extend-Rx® Technology — 5α-Androstan-3β-Ol-17-One (a DHEA derivative shown to increase testosterone and improve muscle-to-fat ratio), Chrysin 99% (an aromatase-inhibiting flavone), Indole-3-Carbinol (promotes conversion of estrogen to its less potent forms), Eurycoma Longifolia 150:1 Extract (standardized to 30% Glyco-Proteins), Muira Puama 20:1 Extract, Quercetin, Coumestrol 40%, and the bioavailability-enhancing pair 6,7-Dihydroxybergamottin and Naringen. Only about 2% of testosterone in normal men circulates freely and able to interact with cellular receptors to trigger muscle-building activity — the rest is bound to SHBG or albumin. Estrogenex 2nd Generation is designed to help free up more of that bound testosterone while minimizing estradiol and DHT production, whether you're an aging male looking to restore healthy testosterone-to-estradiol ratios or a bodybuilder chasing an estrogen-squashing, testosterone-unleashing hard, lean physique. Compared to Hi-Tech's stronger Estrogenex Depot (which leans heavier on aromatase inhibition), 2nd Generation is less aggressive on estrogen blocking and makes up for it with stronger testosterone-boosting botanicals (Eurycoma Longifolia, Quercetin, Muira Puama). Take 1 tablet three times daily, best near mealtime. 90 tablets provides a 30-day supply.†
Supplement Facts — Hi-Tech Pharmaceuticals Estrogenex 2nd Generation (Per 3 Tablets / 30 Servings)
Proprietary Blend with Extend-Rx® Technology — 600mg
5α-Androstan-3β-Ol-17-One — DHEA derivative, increases testosterone and improves muscle-to-fat ratio
Chrysin (99%) — inhibits aromatase, the enzyme converting testosterone to estrogen
Indole-3-Carbinol (IC3) — promotes conversion of estrogen to its less potent, less active metabolite forms
Eurycoma Longifolia 150:1 Extract (standardized to 30% Glyco-Proteins) — traditional testosterone-supporting botanical
Muira Puama 20:1 Extract (Root) — traditional vitality and libido-supporting botanical
Quercetin — flavonoid antioxidant with aromatase-modulating research
Coumestrol 40% (Flavonoid) — phytoestrogen with documented estrogen receptor modulation research
6,7-Dihydroxybergamottin (Fruit) — CYP3A4 inhibitor, bioavailability enhancer
Naringen (Fruit) — citrus flavonoid, bioavailability enhancer
Other Ingredients: Microcrystalline Cellulose, Starch, Stearic Acid, Magnesium Stearate, Sodium Starch Glycolate, Triacetin, Silica, FD&C Red #3, FD&C Yellow #6
Individual ingredient doses within the 600mg blend not separately disclosed — proprietary blend format
90 tablets — 30-day supply at 3 tablets daily
Take 1 tablet three times daily, best near mealtime
No PCT required — natural test/estrogen-balance formula, not a suppressive prohormone
California Prop 65 Warning applies.
Why Testosterone's "Free" State Matters
The male hormone testosterone moves about the body in a free state — about 2% in normal men — or bound to one of two plasma proteins: sex hormone-binding globulin (SHBG) or albumin. Only when testosterone is in its free state can it interact with cellular receptors to trigger muscle-building activity. This is the core premise behind Estrogenex 2nd Generation's design: even when total testosterone is adequate, if too much of it is bound to SHBG or albumin, the body can't actually use it for the anabolic effects that matter. The formula's combination of ingredients targets both increasing overall testosterone production and reducing the factors (like elevated estrogen and its downstream effects on SHBG) that keep more testosterone locked in its bound, unusable state.†
5α-Androstan-3β-Ol-17-One and Chrysin — The Hormonal Core
5α-Androstan-3β-Ol-17-One is a DHEA derivative shown to increase testosterone levels and improve muscle-to-fat ratio. Chrysin, standardized to 99% purity, has been shown to inhibit aromatase — the enzyme that converts testosterone into estrogen — meaning higher relative levels of testosterone remain available rather than being converted away. These two compounds work together on the production and conversion sides of the testosterone-estrogen equation simultaneously.†
Indole-3-Carbinol and Coumestrol — Estrogen Metabolism Support
Indole-3-Carbinol (IC3) is shown to balance hormone levels by promoting the conversion of estrogen to its less potent forms — specifically favoring the 2-hydroxyestrone metabolite pathway over the more biologically active 16-hydroxyestrone pathway, which could help reduce the overall effects of estrogen in the body without eliminating it entirely (a meaningful distinction, since men do require some baseline estrogen for bone density and cardiovascular health). Coumestrol, a phytoestrogen standardized to 40%, has documented research on estrogen receptor modulation, adding a complementary dimension to the formula's estrogen-management strategy.†
Eurycoma Longifolia, Muira Puama, and Quercetin — The Testosterone-Boosting Trio
This is where Estrogenex 2nd Generation differentiates itself from Hi-Tech's stronger Estrogenex Depot, which leans more heavily on multiple aromatase inhibitors. 2nd Generation trades some of that aggressive estrogen-blocking strength for a more robust testosterone-boosting botanical stack: Eurycoma Longifolia (Tongkat Ali) at a substantial 150:1 extraction ratio standardized to 30% Glyco-Proteins is one of the most researched natural testosterone-supporting botanicals, with documented effects on free testosterone and libido. Muira Puama, a traditional Brazilian botanical, contributes vitality and libido support. Quercetin rounds out the trio with antioxidant and aromatase-modulating research of its own.†
6,7-Dihydroxybergamottin and Naringen — Making the Rest of the Formula Work Harder
These two citrus-derived compounds are potent CYP3A4 enzyme inhibitors — the same "grapefruit effect" compounds used in Hi-Tech's Pain-Rx formula. By inhibiting CYP3A4, they reduce first-pass hepatic metabolism of the formula's other active compounds, effectively amplifying the bioavailability of the entire 600mg blend rather than letting a significant fraction be broken down before it can act.†
Estrogenex 2nd Generation vs. Estrogenex Depot — Choosing the Right Version
Estrogenex Depot tends to be stronger on estrogen blocking, using multiple aromatase inhibitors, and less focused on testosterone boosting. Estrogenex 2nd Generation is less aggressive in terms of estrogen blocking, making up for it with stronger testosterone-boosting ingredients (Eurycoma Longifolia, Quercetin, Muira Puama). Choose Depot if aggressive estrogen control is the primary goal (such as coming off a wetter prohormone cycle); choose 2nd Generation if you want a more balanced test-support and mild estrogen-management formula for general anti-aging or bodybuilding use, without needing maximal aromatase suppression.†
Frequently Asked Questions
Do I need PCT after using Estrogenex 2nd Generation?
No — this is a natural testosterone and estrogen-balance support formula built on botanicals and a mild DHEA derivative, not a suppressive androgenic prohormone. No PCT is required.†Who is Estrogenex 2nd Generation best suited for?
It's positioned for two overlapping groups: aging men looking to restore healthy testosterone-to-estradiol ratios as part of an anti-aging strategy, and bodybuilders or athletes wanting estrogen management and testosterone support for a harder, leaner physique — with or without a prohormone cycle in the picture.†How is this different from Novedex XT or Arimiplex?
Novedex XT and Arimiplex are both built around potent steroidal aromatase inhibitors (including Arimistane) specifically for post-cycle recovery from suppressive prohormones. Estrogenex 2nd Generation uses a milder DHEA derivative alongside botanical aromatase modulators and testosterone-supporting herbs — appropriate for standalone, ongoing use without the same PCT-specific positioning.†Is Estrogenex 2nd Generation appropriate for tested athletes?
Given the inclusion of a DHEA derivative (5α-Androstan-3β-Ol-17-One), tested athletes should verify current status with their governing body, as DHEA metabolites are commonly monitored substances. Consult your sport's regulations before use.†
How to Take Hi-Tech Pharmaceuticals Estrogenex 2nd Generation
Take 1 tablet three times daily, best taken near mealtime. 90 tablets provides a 30-day supply at the full daily dose. Consistent daily use is recommended, as hormone-modulating botanicals and testosterone-support compounds work cumulatively over weeks rather than producing an acute effect. Consult a physician before use if you have any medical condition or are taking any prescription medications. Not intended to treat, cure, diagnose, or prevent any disease and should not replace recommendations from your healthcare professional. California Prop 65 Warning applies.†
Why Buy at Get Yok'd
Real-time inventory across all five Southern California stores
Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
Authorized Hi-Tech Pharmaceuticals retailer — carrying Estrogenex 2nd Generation alongside Estrogenex Depot and the full Hi-Tech test support and anti-aging lineup
Staff who can help you choose between Estrogenex 2nd Generation and Estrogenex Depot based on your specific goals
One of the best loyalty programs in the supplement industry — earn rewards on every purchase
Who Should Exercise Caution with Estrogenex 2nd Generation
Not for women — this is a men's hormone-support formula
Individuals with prostate conditions should consult a physician before use — DHEA-derivative compounds may affect prostate tissue
Individuals taking medications metabolized by CYP3A4 should consult a physician — 6,7-Dihydroxybergamottin and Naringen can significantly increase blood levels of many prescription drugs
Individuals with hormone-sensitive conditions should consult a physician before use
Consult a physician before use if taking any prescription medications or having any medical condition
California Prop 65 Warning applies.
Keep out of reach of children.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.