USP Labs - Yok3d - 90 Tablets

USP Labs Yok3d is the original stimulant-free nitric oxide pump tablet — reformulated and back with a five-compound non-stim pump formula built around two distinct NO production pathways operating simultaneously. Per 3-tablet serving: 1,500mg Inositol-Stabilized Citrulline Silicate (as Nitro-Rx®), 1,500mg Arginine Nitrate, 99mg Potassium (from Nitrosigine®), 250mg Red Wine Extract (50% Polyphenols), and 250mg French Grape Seed Extract (95% OPC). Zero caffeine. Zero stimulants. 30 servings per 90-tablet bottle — take on workout days only. Take 3 tablets 60-90 minutes before training on an empty stomach for best results. Do not exceed 6 tablets per day. Do NOT combine with erectile dysfunction medications or additional nitrate-containing supplements. Do not use antibacterial mouthwash within 4 hours of taking Yok3d. Stacks with Jack3d for a complete energy and pump pre-workout protocol. Safe for tested athletes. California Prop 65 Warning applies.†

IMPORTANT WARNINGS: Do NOT use Yok3d if you are taking erectile dysfunction medication. Do NOT take additional nitrates from medication or other supplements alongside Yok3d. Do NOT use antibacterial mouthwash within 4 hours of consuming Yok3d — antibacterial mouthwash kills the oral bacteria required for nitrate-to-nitrite conversion that Arginine Nitrate depends on for its mechanism.

Supplement Facts — USP Labs Yok3d (Per 3 Tablets / 30 Servings)

• Potassium (from Nitrosigine®) — 99mg (3% DV)
• Inositol-Stabilized Citrulline Silicate (as Nitro-Rx®) — 1,500mg
• Red Wine Extract (standardized to 50% Polyphenols) — 250mg
• French Grape Seed Extract (95% OPC / Oligomeric Proanthocyanidins) — 250mg
• Arginine Nitrate — 1,500mg

• Other Ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, FD&C Red #40, Titanium Dioxide, FD&C Blue #2
• Zero stimulants. Zero caffeine.
• 90 tablets per container — 30 three-tablet servings
• Take on workout days only — not a daily supplement
• Take 3 tablets 60-90 minutes before training on an empty stomach (optimal)
• OR take 3 tablets 2-3 hours before training with or without food
• If training within 2 hours of waking: take 3 tablets upon waking with or without food
• Do not exceed 6 tablets per day
• Do NOT combine with erectile dysfunction medications (nitrate contraindication)
• Do NOT take additional nitrates from other medications or supplements alongside Yok3d
• Do NOT use antibacterial mouthwash within 4 hours of taking Yok3d
• Safe for tested athletes — no WADA-prohibited compounds
• Safe for women
• Stack with Jack3d for energy + pump combination
• California Prop 65 Warning applies.

The USPLabs Legacy and Yok3d's Return

USPLabs built one of the most iconic product catalogs in the history of the supplement industry. Jack3d (the original) was one of the best-selling pre-workouts ever made. Yok3d was the companion pump pill designed to stack alongside it. The original USPLabs, LLC (Texas company) is no longer operating. The current USPLabs brand is operated under Hi-Tech Pharmaceuticals Inc — the same company that owns and operates USPLabs' classic product line including Jack3d, Yok3d, OxyElite Pro, and other legacy products. The reformulated Yok3d retains the pump tablet format and non-stimulant design philosophy of the original while updating the formula to reflect the current NO science landscape — particularly the addition of Arginine Nitrate as a second mechanistic pathway alongside the Citrulline Silicate (Nitro-Rx) that anchored the original Yok3d formula.†

The Two-Pathway NO Architecture — Why Yok3d Works Differently From Powder Pump Products

Most pump pre-workouts address NO production through one pathway: L-Citrulline converts to arginine in the kidney, arginine is the substrate for eNOS (endothelial nitric oxide synthase), and eNOS produces NO. Yok3d addresses this same pathway through its Citrulline Silicate (Nitro-Rx) and Nitrosigine compounds — but adds a second, completely distinct NO pathway through Arginine Nitrate. Understanding both pathways explains why Yok3d's pump character is described differently from products that only use Citrulline.†

The Five Ingredients — What Each One Does

Inositol-Stabilized Citrulline Silicate (Nitro-Rx®) — 1,500mg — Primary eNOS-Mediated Pump

Nitro-Rx® is a proprietary compound combining L-Citrulline with silicon (as silicate) and Inositol for stabilization. The citrulline component provides the established NO production mechanism: L-Citrulline converts to arginine in the kidney, arginine serves as substrate for eNOS in vascular endothelial cells, and eNOS catalyzes the production of NO — which activates soluble guanylyl cyclase in vascular smooth muscle, raising cGMP and producing vasodilation. The silicate component adds silicon — a mineral concentrated within arterial walls where it helps maintain structural integrity of the vasculature and has independent vasodilatory activity through silicon's effects on arterial elasticity. The Inositol provides stabilization of the citrulline-silicate complex for consistent delivery.†

The combination produces documented improvements in arginine plasma levels extending up to six hours post-dose — a sustained NO production window that significantly outlasts the 2-3 hour arginine spike from standard oral arginine supplementation. USPLabs references a 2015 Journal of the International Society of Sports Nutrition publication (Rood-Ojalvo et al.) on inositol-stabilized arginine silicate as a workout ingredient confirming performance benefits from this specific compound.†

Arginine Nitrate — 1,500mg — The Nitrate-Nitrite-NO Second Pathway

Arginine Nitrate provides two simultaneous mechanisms from a single compound: L-Arginine (the direct eNOS substrate that complements the Citrulline-derived arginine) plus dietary Nitrate (which feeds the completely separate nitrate-nitrite-NO pathway). This dual contribution is the primary design advancement in the reformulated Yok3d versus the original formula.†

The nitrate-nitrite-NO pathway operates through a fundamentally different enzymatic route from the arginine-eNOS system. Dietary nitrates from Arginine Nitrate are first reduced to nitrite by oral bacteria on the tongue — this is the step that antibacterial mouthwash disrupts, which is why Yok3d explicitly warns against antibacterial mouthwash within 4 hours of use. The nitrite is then absorbed into systemic circulation, where it is reduced to NO by nitrite reductases in vascular tissue under hypoxic conditions — specifically during intense exercise when oxygen tension in contracting muscle is reduced. This means nitrate-derived NO production actually increases during the most intense moments of training, precisely when NO demand is highest and the arginine-eNOS system is most stressed by substrate competition. The two pathways are complementary and additive: the eNOS pathway from Citrulline/Arginine provides baseline NO production, while the nitrate-nitrite pathway provides additional NO specifically during peak exercise intensity.†

USPLabs references a 2015 JISSN publication (Falcone et al.) on the acute hemodynamic effects of arginine nitrate on exercise-induced vasodilation — confirming the specific compound's documented performance on exercise blood flow. The endurance implications of Arginine Nitrate's VO2 max effects are specifically highlighted: nitrate has been shown in multiple studies to reduce the oxygen cost of submaximal exercise (reducing how much oxygen is required for a given workload), improve time to exhaustion, and increase the sustainable power output in endurance activities. For strength athletes, this translates to more reps at heavier weights before oxygen-limited fatigue sets in.†

Potassium (from Nitrosigine®) — 99mg — Vascular Potassium and Additional Arginine Support

Nitrosigine® is Nutrition21's patented inositol-stabilized arginine silicate — one of the most researched branded arginine delivery compounds in sports nutrition, with multiple human clinical trials documenting improvements in cognitive function, blood flow, and exercise performance. In Yok3d, Nitrosigine is listed for its Potassium contribution specifically — potassium is the primary intracellular cation that governs vascular smooth muscle membrane potential and influences vasodilation. Adequate potassium supports the vascular relaxation that underpins pump physiology. The inclusion of Nitrosigine also provides additional inositol-stabilized arginine silicate beyond the Nitro-Rx compound, contributing further to the arginine pool available for eNOS-mediated NO production.†

Red Wine Extract (50% Polyphenols) — 250mg — Glycerol-Like Hyperhydration and Vasodilation

USPLabs makes a specific and important claim about their Red Wine Extract that distinguishes it from standard red wine polyphenol supplements: this extract is standardized to both 50% Polyphenols AND 30% Glycerol content — making it simultaneously a polyphenol antioxidant/vasodilator and a glycerol source for osmotic hyperhydration. Standard glycerol monostearate (GMS) powders typically contain only 1.5-5% actual glycerol — USPLabs' Red Wine Extract contains 30% molecular glycerol, making it 6-20x more potent as a glycerol source per gram than standard GMS. The glycerol component draws water into the vascular space through osmotic pressure, expanding plasma volume and producing the engorged, vascular appearance associated with glycerol hyperhydration. The polyphenol component (particularly resveratrol and OPC from red wine) supports vasodilation through NO-independent pathways including endothelium-derived hyperpolarizing factor (EDHF) production. Competitive bodybuilders have used red wine before competitions specifically for its vasodilation and vascularity-enhancing properties — Yok3d captures this effect in concentrated extract form.†

French Grape Seed Extract (95% OPC) — 250mg — Endothelial Health and Post-Exercise NO Amplification

French Grape Seed Extract at 95% OPC (Oligomeric Proanthocyanidins) is one of the most potent plant-derived antioxidant and endothelial support compounds available. OPCs at high standardization have been shown in clinical studies to substantially increase NO production specifically in the period following exercise — the post-exercise NO amplification that promotes recovery, continued blood flow for nutrient delivery to muscle, and extended pump duration after the session has ended. OPCs protect the vascular endothelium from oxidative damage through powerful antioxidant activity, maintain endothelial cell function and NO synthase activity, and inhibit ACE (angiotensin-converting enzyme) to reduce vasoconstrictive signaling — all of which contribute to maintaining the vasodilatory state that produces the pump. USPLabs references a published study specifically on French Grape Seed OPC's ability to increase NO substantially after exercise.†

The Timing Rationale — Why 60-90 Minutes Before Training

Yok3d's specific dosing timing recommendation (60-90 minutes pre-workout on empty stomach) is grounded in the pharmacokinetics of the nitrate pathway. Unlike Citrulline's arginine-eNOS mechanism which peaks in 60-90 minutes, the nitrate-nitrite-NO pathway requires oral bacteria to first convert dietary nitrate to nitrite — a process that takes approximately 60-90 minutes for meaningful nitrite accumulation in the bloodstream. Taking Yok3d 60-90 minutes before training ensures that nitrite levels (and thus nitrate-derived NO availability) are peaking precisely when the training session begins. This timing is specifically designed around the nitrate kinetics — not conventional pre-workout window thinking. Taking Yok3d immediately before training (30 minutes) would mean the nitrate pathway hasn't converted adequately and the full dual-pathway NO effect hasn't been activated at session start.†

The antibacterial mouthwash warning directly relates to this timing: commercial antibacterial mouthwashes (Listerine, etc.) kill the oral bacteria on the tongue that perform the nitrate-to-nitrite reduction. If these bacteria are killed by mouthwash within 4 hours of taking Yok3d, the nitrate from Arginine Nitrate cannot be converted to nitrite, and the nitrate-nitrite-NO pathway is completely blocked for that session. Yok3d's nitrate pathway effectiveness is entirely dependent on the oral microbiome being intact at the time of ingestion.†

Yok3d vs. Powder Pump Products — Why Pills?

USPLabs chose the tablet format for Yok3d deliberately and makes the argument explicitly: pump pills eliminate the palatability and mixing problems that affect powder pump products. Many pump powders — particularly those containing HydroPrime Glycerol — have severe clumping and mixing problems due to hygroscopic ingredients. They require large scoops mixed in significant amounts of liquid, creating a bulky pre-workout drink that some users find filling or uncomfortable before training. Yok3d's tablet format requires no mixing, no shaker, no water (beyond a sip to swallow), and produces no GI bulk or pre-workout heaviness. The concentrated tablet delivery also allows Yok3d to stack with any pre-workout of choice — simply take the tablets 60-90 minutes before training and follow with your caffeinated pre-workout 30 minutes before. The two products hit different timing windows and cover different mechanisms simultaneously.†

Frequently Asked Questions

1. Why can't I use antibacterial mouthwash before taking Yok3d?
   The Arginine Nitrate in Yok3d must be converted to nitrite by oral bacteria on the tongue before it enters the nitrate-nitrite-NO pathway. Antibacterial mouthwash kills these bacteria, blocking the conversion and preventing the nitrate pathway from working. Without oral bacteria, the Arginine Nitrate in your serving is essentially wasted — the nitrate cannot be reduced to nitrite, cannot be converted to NO, and the second NO pathway in Yok3d's dual-mechanism design is eliminated. If you use mouthwash, use it more than 4 hours before taking Yok3d and allow the oral bacteria to repopulate before consuming the product.†
2. Why does Yok3d warn against erectile dysfunction medications?
   Prescription erectile dysfunction medications (sildenafil/Viagra, tadalafil/Cialis, vardenafil/Levitra) work by inhibiting PDE5 — the enzyme that breaks down cGMP in vascular smooth muscle. Nitric oxide increases cGMP to produce vasodilation, and PDE5 inhibitors prevent cGMP breakdown, amplifying NO's vasodilatory effect. Both nitrates and PDE5 inhibitors increase NO-mediated vasodilation through different mechanisms. The combination can produce additive or synergistic hypotension — a severe drop in blood pressure that can cause dizziness, fainting, or cardiovascular events. This is a documented and serious drug interaction. This warning is non-negotiable — do not take Yok3d if you use ED medication.†
3. Can Yok3d be stacked with pre-workouts that already contain Citrulline?
   Yes — this is explicitly how Yok3d is designed to be used. Taking Yok3d 60-90 minutes before training (for the nitrate kinetics) and a Citrulline-containing pre-workout 30 minutes before training combines both the nitrate-nitrite pathway from Yok3d and the eNOS pathway from the pre-workout's Citrulline for maximum dual-mechanism NO coverage. The total Citrulline from both sources stacks additively. USPLabs specifically recommends stacking with Jack3d for this combined effect.†
4. Is Yok3d appropriate for tested athletes?
   Yes. Inositol-Stabilized Citrulline Silicate, Arginine Nitrate, Potassium, Red Wine Polyphenol Extract, and French Grape Seed Extract are all permitted by WADA and the NCAA. Yok3d contains no stimulants, no prohormones, no peptide hormones, and no banned compounds. Tested athletes can use Yok3d without regulatory concern.†

How to Take USP Labs Yok3d

Take 3 tablets 60-90 minutes before training on an empty stomach for optimal nitrate conversion timing. If scheduling does not allow 60-90 minutes: take 3 tablets 2-3 hours before training with or without food. If training within 2 hours of waking: take 3 tablets immediately upon waking. Do not exceed 6 tablets per day. Use on workout days only — this is not a daily supplement. Do not use antibacterial mouthwash within 4 hours of consuming Yok3d. Do not combine with erectile dysfunction medications. Do not combine with additional nitrate-containing medications or supplements. Stack with Jack3d for combined energy and pump support — take Yok3d 60-90 minutes before training, Jack3d 30 minutes before training. Safe for women and tested athletes. Not for persons under 18. Consult a physician before use if taking any prescription medications. California Prop 65 Warning applies.†

Why Buy at Get Yok'd

• Real-time inventory across all five Southern California stores
• Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
• Authorized USP Labs / Hi-Tech Pharmaceuticals retailer — carrying the full USPLabs lineup including Jack3d
• Staff who can walk you through the Yok3d + Jack3d stack protocol in person
• One of the best loyalty programs in the supplement industry — earn rewards on every purchase

Who Should Not Take Yok3d

• Not for persons under 18 years of age
• Not for pregnant or nursing women
• Do NOT use if taking erectile dysfunction medications (sildenafil, tadalafil, vardenafil, or similar) — dangerous hypotension risk
• Do NOT combine with nitrate medications (nitroglycerin, isosorbide mononitrate, isosorbide dinitrate) — dangerous hypotension risk
• Individuals with low blood pressure should exercise caution — the dual NO pathway produces significant vasodilation
• Individuals with high blood pressure, cardiac arrhythmia, stroke history, heart disease, liver disease, kidney disease, or thyroid disease should consult a physician before use
• Individuals with seizure disorders or psychiatric illness should consult a physician
• Individuals with diabetes should consult a physician — Arginine Nitrate affects insulin sensitivity
• Consult a physician before use if taking any prescription or over-the-counter medications
• Discontinue use 2 weeks prior to surgery
• Do not combine with alcohol
• California Prop 65 Warning applies.
• Keep out of reach of children.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.