Transparent Labs - Gut Health - 60 Capsules

Transparent Labs Probiotic Advanced Gut Health Formula delivers 100 billion colony-forming units (CFUs) from 10 clinically studied probiotic strains across Lactobacilli, Bifidobacteria, and Streptococcus species — each strain strain-coded for identification and included at a disclosed, individual CFU count with no strains hidden behind a combined blend total. Inulin FOS added as built-in prebiotic substrate. Vegan HPMC capsule. Gluten-free, non-GMO. Third-party tested. 60 capsules, 30 servings. The probiotic that actually tells you what is in it and how much of each strain.†

Supplement Facts — Transparent Labs Gut Health (Per 2 Capsule Serving)

Probiotic Blend — 100 Billion CFU Total

• Lactobacillus acidophilus (LA-14) — 22 Billion CFU
• Lactobacillus rhamnosus (LR-32) — 15 Billion CFU
• Lactobacillus casei (LC-11) — 10 Billion CFU
• Lactobacillus plantarum (LLP-115) — 10 Billion CFU
• Lactobacillus paracasei (LPC-37) — 10 Billion CFU
• Bifidobacterium lactis (BL-04) — 10 Billion CFU
• Lactobacillus salivarius (LS-33) — 5 Billion CFU
• Streptococcus thermophilus (ST-21) — 5 Billion CFU
• Bifidobacterium bifidum (BB-02) — 5 Billion CFU
• Bifidobacterium breve (BB-03) — 5 Billion CFU

Other Ingredients

• Inulin Fructooligosaccharide (FOS) Powder — 100mg (prebiotic substrate)
• Hypromellose (HPMC) vegan capsule, Calcium Carbonate, Vegetable Magnesium Stearate, Non-GMO Maltodextrin (carrier), Silicon Dioxide
• No artificial anything. Fully disclosed individual strain CFU counts. No combined-blend hiding.
• Vegan. Gluten-free. Non-GMO. Third-party tested.
• 60 capsules. 30 servings (2 capsules daily).

What's Inside Transparent Labs Gut Health — Ten Strains, One Formula

Why the Gut Microbiome Matters for Athletes and Active Individuals

The gut microbiome — the estimated 38 trillion microorganisms inhabiting the gastrointestinal tract — is not just relevant to digestion. Research over the past decade has established the gut as a central regulatory organ in immune function, endocrine signaling, cognitive performance, and body composition. Approximately 70-80% of the immune system resides in gut-associated lymphoid tissue (GALT), meaning the state of the gut microbiome directly determines the magnitude and quality of immune response. The gut-brain axis connects intestinal microbiome activity to central nervous system function through vagal nerve signaling, enteric neurotransmitter production, and microbial metabolite circulation — meaning gut dysbiosis (imbalance in microbial populations) correlates with cognitive fog, mood instability, and reduced mental resilience alongside the physical symptoms.†

For athletes specifically, intense training creates conditions that are actively hostile to gut microbiome diversity: exercise-induced intestinal permeability (loosening of tight junction proteins in the intestinal wall), altered gut motility under physical stress, reduced splanchnic blood flow during maximal effort, post-exercise immune suppression windows, and — for many athletes — antibiotic use for illness that indiscriminately depletes beneficial bacteria alongside pathogens. High protein intake without adequate fiber further shifts microbial populations toward less favorable species. The result is that serious athletes are among the highest-risk populations for gut microbiome disruption, and among those who stand to benefit most from targeted, multi-strain probiotic support.†

The CFU Count Problem — Why 100 Billion and Why It Matters

The gut microbiome contains hundreds of billions of microorganisms across hundreds of species. Probiotic supplements at 1-5 billion CFUs — the dose found in most grocery store probiotic products — deliver a meaningful number of bacteria in absolute terms, but represent a relatively modest intervention relative to the existing microbiome population and the ongoing intestinal environment that determines microbial survival. Research on probiotic dosing consistently demonstrates dose-dependent responses, with higher CFU counts producing more robust effects on microbiome composition, immune markers, and digestive outcomes.†

At 100 billion CFUs per serving, Transparent Labs Gut Health is positioned at the high end of the clinical probiotic dose range — the territory where meaningful, measurable effects on gut microbiome composition and systemic biomarkers have been documented in human research rather than the sub-threshold doses that produce minimal, inconsistent results. This is not a number chosen for marketing impact — it reflects the dose at which multi-strain probiotic interventions have demonstrated statistically significant effects in the most relevant clinical literature.†

Why Ten Strains Instead of One or Two

Different probiotic strains colonize different regions of the GI tract, interact with different immune cell populations, produce different metabolites, and support different aspects of gut function. A single-strain probiotic at 100 billion CFUs saturates one niche in the intestinal ecosystem — useful for specific targeted outcomes, but limited in the breadth of support it provides. The 10-strain formula in Transparent Labs Gut Health distributes the 100 billion CFU total across strains that work through different mechanisms and colonize different intestinal sites, providing broader and more comprehensive microbiome support than any single-strain or dual-strain formula at equivalent total CFUs.†

The Ten Strains — What Each Does

Lactobacillus acidophilus (LA-14) — 22 Billion CFU. The most clinically researched Lactobacillus species and the dominant strain in this formula at 22 billion CFUs. L. acidophilus colonizes the small intestine, produces lactic acid that lowers intestinal pH (creating an unfavorable environment for pathogenic bacteria), enhances the integrity of the intestinal epithelial barrier, supports lactase enzyme activity for lactose digestion, and directly stimulates immune cell activation in gut-associated lymphoid tissue. LA-14 is the strain-coded designation indicating a specific clinically characterized strain with documented bioactivity.†

Lactobacillus rhamnosus (LR-32) — 15 Billion CFU. L. rhamnosus is among the most studied probiotics for immune support — it has been researched extensively for its effects on respiratory and gastrointestinal immune defense, including documented reductions in the incidence and duration of upper respiratory infections in healthy populations. It also demonstrates strong epithelial barrier-supporting activity and has been studied for its role in managing antibiotic-associated diarrhea and maintaining microbiome stability during and after antibiotic use.†

Lactobacillus casei (LC-11) — 10 Billion CFU. L. casei has been researched primarily for its immune-modulating effects through interaction with toll-like receptors on intestinal immune cells, stimulating both innate and adaptive immune responses. It competes effectively against pathogenic bacteria for intestinal colonization sites and adhesion receptors, helping to displace less favorable species from the intestinal wall.†

Lactobacillus plantarum (LLP-115) — 10 Billion CFU. L. plantarum has one of the broadest pH and temperature tolerances of any Lactobacillus species — meaning it survives the gastric acid transit into the small intestine more reliably than many competing strains. Research on L. plantarum documents effects on gut permeability reduction, anti-inflammatory cytokine modulation, and direct antioxidant activity through production of short-chain fatty acids.†

Lactobacillus paracasei (LPC-37) — 10 Billion CFU. L. paracasei has been specifically studied for its effects on immune response modulation and allergy-related immune pathways. Research demonstrates effects on regulatory T-cell populations and Th1/Th2 immune balance — mechanisms relevant to maintaining healthy inflammatory tone in athletes with high training loads.†

Bifidobacterium lactis (BL-04) — 10 Billion CFU. BL-04 is among the most researched Bifidobacterium strains for athletic and active populations specifically. A clinical trial on BL-04 in physically active adults documented statistically significant reductions in upper respiratory illness incidence, reduction in immune suppression markers following high-intensity training, and improvements in immune cell function during post-exercise recovery windows. For athletes experiencing the well-documented post-exercise immune suppression that follows high-intensity training, BL-04 at this dose represents direct evidence-based support.†

Lactobacillus salivarius (LS-33) — 5 Billion CFU. L. salivarius colonizes both the small intestine and the oral cavity, producing antimicrobial compounds that inhibit the growth of pathogenic bacteria in both environments. It has been researched for its effects on periodontal health alongside gut microbiome support.†

Streptococcus thermophilus (ST-21) — 5 Billion CFU. S. thermophilus produces lactase enzyme that directly supports the digestion of lactose — relevant for the substantial proportion of the population with reduced lactase expression. It also produces exopolysaccharides that contribute to intestinal mucous layer integrity, the first line of defense against pathogen invasion of the intestinal epithelium.†

Bifidobacterium bifidum (BB-02) — 5 Billion CFU. B. bifidum colonizes the large intestine and has documented effects on protecting intestinal epithelial cell health from oxidative damage, reducing inflammation in the colon, and enhancing the production of secretory IgA (the primary antibody in the gut lumen that neutralizes pathogens before they can adhere to the intestinal wall).†

Bifidobacterium breve (BB-03) — 5 Billion CFU. B. breve ferments a wider range of dietary fibers than most Bifidobacterium species, producing short-chain fatty acids (SCFAs) including butyrate — the primary energy source for colonocytes (colon cells) and a direct regulator of intestinal barrier integrity and anti-inflammatory gene expression. B. breve has also been studied for effects on fat accumulation and body composition in overweight populations.†

Inulin FOS — The Built-In Prebiotic

Inulin fructooligosaccharide (FOS) is a soluble prebiotic fiber that probiotic bacteria — particularly Bifidobacteria — use as a preferred fermentation substrate. Including FOS alongside the probiotic strains provides the organisms with an immediate food source in the intestinal environment, supporting their survival and colonization efficiency. This prebiotic addition is particularly relevant for users who may not consistently consume high-fiber diets — the FOS ensures the probiotic strains have substrate available regardless of dietary fiber intake on any given day. For optimal prebiotic + probiotic synergy, Transparent Labs recommends stacking with Transparent Labs Prebiotic Greens.†

Frequently Asked Questions About Transparent Labs Gut Health

1. Should I take probiotics on an empty stomach or with food?
   Transparent Labs recommends taking on an empty stomach — either at least 30 minutes before eating or 2-3 hours after a meal. The rationale is gastric acid exposure: stomach acid pH drops significantly during and after eating, creating a more acidic environment that reduces probiotic viability before the capsule can transit to the small intestine. On an empty stomach, gastric acid levels are lower and transit time faster, giving the encapsulated bacteria the best chance of reaching the small intestine intact. That said, the HPMC capsule provides some protection during acid transit, so taking with a light meal is a reasonable compromise for those whose routine makes empty-stomach dosing impractical. Consistency of daily use matters more than precise timing.†
2. How long before I notice effects?
   Timeline varies considerably based on the existing state of your gut microbiome going in. Users with significant dysbiosis — those who have recently completed antibiotics, have a history of highly processed food intake, or have been experiencing persistent GI symptoms — often notice meaningful changes within 1-2 weeks of consistent daily use as beneficial bacteria begin establishing colonies and displacing less favorable populations. For users with relatively healthy baseline gut function taking Gut Health for immune support, performance recovery, or general microbiome maintenance, subjective effects may be more subtle but the underlying microbiome improvements build consistently over 4-8 weeks of daily use. The research on most well-characterized probiotic strains shows consistent effects when measured at 4+ week timepoints — daily consistent use over that window is the minimum evaluation period.†
3. Can I take this with antibiotics?
   A physician should be consulted on this, as the answer depends on which antibiotic you are taking and for what condition. The general practice for probiotic use during antibiotic therapy is to take the probiotic at least 2 hours separate from the antibiotic dose — this reduces the exposure of the probiotic organisms to the antibiotic before it is absorbed. Most research on antibiotic-associated diarrhea prevention uses L. rhamnosus (present at 15 billion CFU here) and L. acidophilus (22 billion CFU) taken during the antibiotic course, with continuation for 4 weeks post-antibiotic to support microbiome recovery. Consult your prescribing physician before making any changes to your medication regimen.†
4. How does Gut Health pair with Transparent Labs Prebiotic Greens?
   They are complementary rather than redundant — this is the prebiotic + probiotic pairing that Transparent Labs specifically recommends as their complete gut health stack. Prebiotic Greens supplies the fiber substrate that probiotic bacteria ferment into short-chain fatty acids and use as colonization support (organic acacia fiber, green banana flour, Jerusalem artichoke, chicory root). Gut Health supplies the live probiotic organisms themselves. The combination addresses both sides of gut microbiome support: the food supply for the bacteria (prebiotics) and the bacteria themselves (probiotics). Neither product duplicates the function of the other.†

How to Take Transparent Labs Gut Health

Take 2 capsules daily with a full glass of water, preferably on an empty stomach (at least 30 minutes before eating or 2-3 hours after a meal) for optimal bacterial survivability through gastric acid transit. Store in a cool, dry place — probiotics are living organisms whose viability depends on appropriate storage conditions. Do not store in a humid environment or in direct heat. Use consistently daily for best results — benefits build with consistent microbiome colonization over weeks of daily use.†

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Who Should Not Take Transparent Labs Gut Health

• Consult a physician before use if you are immunocompromised, have HIV/AIDS, are undergoing chemotherapy, or are on immunosuppressant medications — live probiotic organisms are generally contraindicated in severely immunocompromised individuals
• Consult a physician before use if you have short bowel syndrome, central venous catheters, or any condition affecting intestinal barrier integrity
• Consult a physician before use if pregnant or nursing
• Consult a physician before use if you have any underlying gastrointestinal condition such as Crohn's disease, ulcerative colitis, or irritable bowel syndrome — not because probiotics are harmful in these conditions (research often supports their use) but because medical supervision is appropriate for any supplementation in the context of active GI disease
• Not for use by persons under 18 without physician guidance
• Consult a physician before use if taking antibiotics (take at least 2 hours apart from antibiotic doses)
• Keep out of reach of children

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.