NutraBio - Ashwagandha KSM-66 - 90 Capsules

NutraBio KSM-66 Ashwagandha is a single-ingredient, full-spectrum ashwagandha root extract supplement delivering 600mg of KSM-66 per capsule — one of the highest per-capsule doses available from any brand. One ingredient. No fillers. No binders. No artificial anything. Vegetarian capsule. Third-party tested. Made in the USA. KSM-66 is the most extensively clinical-trial-validated ashwagandha extract on the market, produced from 100% root (no leaves), using a proprietary green chemistry extraction process without alcohol or chemical solvents, and standardized to a minimum 5% withanolides by HPLC. 90 capsules per container. 1-2 capsules daily between meals.†

Supplement Facts — NutraBio KSM-66 Ashwagandha (Per 1 Capsule / 90 Servings)

• KSM-66 Ashwagandha (Withania somnifera)(Root) Extract — 600mg
• Standardized to ≥5% withanolides (HPLC verified)
• 100% root extract — no leaf content
• Other Ingredients: Vegetarian Capsule (Hypromellose, Water)
• No fillers. No binders. No artificial colors, flavors, sweeteners, or excipients.
• Made without gluten or lactose.
• Manufactured in a facility that also processes milk, eggs, and fish.
• Third-party tested for label accuracy and purity.
• Made in USA.
• 90 capsules per container. 1 capsule = 1 serving at 600mg. 2 capsules = 1,200mg.
• Take 1-2 capsules daily between meals, or as directed by a physician.

What KSM-66 Is — and Why the Extraction Process Matters

KSM-66 vs. Generic Ashwagandha

Not all ashwagandha supplements contain the same thing. The ashwagandha market ranges from raw ground root powder (no standardization, variable withanolide content from 0.5-1%) to leaf-and-root combination extracts to root extracts of varying withanolide concentrations using different extraction methods. KSM-66 is a specific, patented ashwagandha root extract developed by Ixoreal Biomed following 14 years of research and development. It is produced exclusively from the root of Withania somnifera — never the leaf — and uses a proprietary "green chemistry" extraction process that employs no alcohol or chemical solvents, relying instead on water and milk proteins as processing agents. This process is what allows KSM-66 to achieve its GRAS (Generally Recognized As Safe) FDA designation and its broad regulatory acceptance across international markets.†

The 5% withanolides standardization is verified by HPLC (High Performance Liquid Chromatography) — the gold standard analytical method for confirming compound concentration in plant extracts. The industry average withanolide content for commodity ashwagandha extracts is 1-2.5%; KSM-66 at 5% represents a meaningfully higher concentration of the bioactive compounds responsible for ashwagandha's documented effects. The practical implication is that 600mg of KSM-66 delivers approximately 30mg of withanolides, while a commodity 600mg ashwagandha extract at 1.5% withanolides delivers only 9mg — one-third of the active compound content at the same labeled dose.†

Why Root Only Matters

The overwhelming majority of clinical research on ashwagandha's adaptogenic, cortisol-reducing, and performance-supporting effects used root-only extracts. Ashwagandha leaves contain withanolides at higher concentrations than the root, but the leaf alkaloid profile is different — leaf extracts are associated with a higher incidence of GI discomfort and are not the form studied in most of the human trials that established ashwagandha's evidence base. In several countries (including Germany, which has strict botanical supplement regulations), ashwagandha leaf extracts are not approved for oral supplementation. KSM-66's root-only sourcing aligns the supplement directly with the research on which its health claims are based — the clinical trials on stress reduction, cortisol, athletic performance, sleep, and sexual function were conducted with root extracts, not combined root-leaf extracts.†

The Clinical Research on KSM-66

KSM-66 has more published, peer-reviewed, double-blind, placebo-controlled human clinical trials behind it than any other ashwagandha extract on the market — over 22 clinical trials at the time of this writing, making it the most researched single ashwagandha ingredient by a significant margin. The key findings from this body of research span five outcome areas.†

Cortisol and Stress Reduction

The benchmark KSM-66 stress study randomized 64 adults with a history of chronic stress to receive 300mg of KSM-66 twice daily (600mg total) or placebo for 60 days. The KSM-66 group showed a 27.9% reduction in serum cortisol levels and significant improvements on every validated stress assessment scale used in the study — the Perceived Stress Scale, the General Health Questionnaire-28, the Depression Anxiety Stress Scale, and the Food Craving Questionnaire. The cortisol reduction was specific, measurable, and clinically meaningful — not a subjective self-reported improvement. A subsequent study found a 22.2% reduction in serum cortisol from KSM-66 supplementation alongside reductions in perceived stress score of 32.74% from baseline.†

Athletic Performance and Muscle Strength

An 8-week double-blind RCT examined the effects of 300mg KSM-66 twice daily in 57 healthy male subjects undergoing resistance training. The KSM-66 group showed significantly greater increases in muscle strength (bench press and leg extension), muscle size (arm and chest measurement), muscle recovery rate (serum CK and lactate dehydrogenase markers), and testosterone levels compared to placebo. The combination of cortisol reduction and testosterone support from KSM-66 produces a more favorable anabolic hormonal environment — reduced cortisol decreases protein catabolism while elevated testosterone supports protein synthesis, shifting the testosterone-to-cortisol ratio that governs muscle growth outcomes.†

Sleep Quality

A randomized double-blind placebo-controlled study of 60 adults found that KSM-66 at 300mg twice daily significantly improved sleep quality on the Pittsburgh Sleep Quality Index, reduced sleep onset latency, increased total sleep time, and improved sleep efficiency compared to placebo over 10 weeks. The mechanism is primarily HPA axis modulation — by reducing cortisol's evening elevation (the "wired but tired" state), ashwagandha facilitates the physiological transition from sympathetic to parasympathetic nervous system dominance that initiates quality sleep. Unlike melatonin or sedative compounds, KSM-66 does not produce grogginess or next-morning cognitive impairment.†

Cognitive Function and Memory

A 2017 study in the Journal of Dietary Supplements found that 300mg of KSM-66 twice daily produced significant improvements over placebo on multiple cognitive function assessments including immediate and general memory, executive function, attention, and information processing speed in healthy adults over 8 weeks. The cortisol-lowering mechanism is relevant here: chronically elevated cortisol impairs hippocampal function (the brain region responsible for memory formation and retrieval) and reduces prefrontal cortex activity (executive function). Reducing cortisol to normal baseline allows these cognitive functions to operate without the neurological impairment that chronic stress produces.†

Thyroid Function

KSM-66 has documented effects on thyroid hormone levels — a study found significant improvements in T3 and T4 levels in individuals with subclinical hypothyroidism following KSM-66 supplementation. This thyroid stimulation is relevant for individuals with suboptimal thyroid function but means that individuals with hyperthyroidism or those taking thyroid medications should consult a physician before use, as KSM-66 may interact with thyroid function and medication requirements.†

NutraBio's Zero-Filler Commitment — Why the Other Ingredients List Matters

The Other Ingredients section of NutraBio KSM-66 contains two items: hypromellose and water — the components of the vegetarian capsule shell. Nothing else. No magnesium stearate. No silicon dioxide. No calcium silicate. No rice flour. No microcrystalline cellulose. No stearic acid. These excipients are present in the vast majority of capsule supplements as manufacturing aids — flow agents, anti-caking compounds, and lubricants that make encapsulation faster and easier for manufacturers. NutraBio's manufacturing process is designed to avoid them, which means longer production times and higher costs but a capsule that is 100% active ingredient and 100% capsule shell with nothing in between.†

For the consumer, this means the 600mg stated on the label is 600mg of KSM-66 and nothing else inside the capsule. It also means NutraBio KSM-66 is compatible with users who have sensitivities to common excipients like magnesium stearate, which some individuals report GI sensitivity to at higher cumulative doses from multiple supplements.†

Dosing — 600mg vs. 1,200mg Daily

The majority of clinical research on KSM-66 used 300mg twice daily (600mg total daily dose). At 600mg per capsule, one NutraBio KSM-66 capsule delivers the entire standard research dose in a single daily serving — making it flexible for users who prefer a single daily capsule at 600mg or a split two-capsule protocol at 1,200mg for users in higher-stress situations or seeking stronger effects. The 600mg single-capsule option covers the 90-capsule container for 90 days at one cap per day (a three-month supply) — competitive value for a premium KSM-66 product. At two capsules daily, the 90-count provides a 45-day supply.†

Timing: between meals is NutraBio's recommendation for most users. For sleep-specific use, taking one capsule 30-60 minutes before bedtime aligns with ashwagandha's documented effects on sleep onset latency. For cortisol management during high-stress periods, splitting two capsules into morning and evening doses covers both the morning cortisol peak and the evening cortisol elevation that disrupts sleep.†

Who Benefits Most From NutraBio KSM-66

KSM-66 is not a category-specific supplement — its effects span multiple outcome areas simultaneously, making it relevant across a wide range of user goals. Athletes in intensive training phases experience elevated cortisol from training stress on top of daily life stress — KSM-66's cortisol reduction improves recovery quality and the testosterone-to-cortisol ratio that determines muscle building outcomes. Contest prep athletes experience compounding cortisol from caloric restriction, high training volume, and the psychological stress of competition preparation — KSM-66 is one of the few supplements with documented effects on all three simultaneously. Professionals and students experiencing cognitive fatigue from chronic psychological stress benefit from KSM-66's memory and executive function improvements alongside the anxiety reduction. Individuals with sleep quality issues driven by evening cortisol elevation or anxiety benefit from ashwagandha's sleep-architecture improvements. Older users experiencing natural testosterone decline benefit from KSM-66's documented testosterone support. The breadth of evidence across all these populations makes KSM-66 one of the few supplements that Get Yok'd staff recommend across essentially every customer demographic — from competitive bodybuilders to weekend warriors to non-athletes looking for daily stress and cognitive support.†

Frequently Asked Questions About NutraBio KSM-66 Ashwagandha

1. How long until I notice results?
   Ashwagandha is an adaptogen — its effects build over consistent daily supplementation rather than producing acute effects from a single dose. Most users notice the first signs of reduced stress reactivity and improved mood stability at 1-2 weeks of daily use. Sleep quality improvements are often noted within the first week. Measurable cortisol reduction and the performance-related benefits (strength, recovery, testosterone) become more apparent at 4-8 weeks of consistent use — the timeframe used in the clinical research. Consistency is required: skipping days delays the accumulation of the adaptogenic effects.†
2. Does ashwagandha interact with thyroid medications?
   KSM-66 has documented effects on thyroid hormone levels (T3 and T4). Individuals taking thyroid medications (levothyroxine, liothyronine, or antithyroid medications) should consult a physician before using any ashwagandha supplement — KSM-66's thyroid-stimulating effect may alter medication requirements. Individuals with known hyperthyroidism should not use KSM-66 without physician guidance.†
3. Is KSM-66 safe for women?
   Yes — KSM-66 research includes studies conducted in women, including documented effects on female sexual function and hormonal health. The cortisol reduction, sleep quality improvement, and cognitive function benefits apply equally to women. KSM-66 is not an androgenic compound — it does not produce masculinizing effects. Women who are pregnant or nursing must not use any ashwagandha supplement.†
4. Can I stack NutraBio KSM-66 with other supplements?
   KSM-66 stacks cleanly with the vast majority of supplements. Its non-stimulant mechanism means it does not interact with caffeinated pre-workouts — it can be taken at a different time of day from training supplements. It complements creatine (by improving the hormonal environment for strength and muscle growth), protein supplements (by supporting recovery through cortisol modulation), and sleep supplements (by adding cortisol-reduction benefits that melatonin or GABA-based products don't provide). The absence of fillers and excipients in NutraBio's formula means minimal interaction risk from inactive ingredients.†

How to Take NutraBio KSM-66 Ashwagandha

Take 1-2 capsules daily between meals, or as directed by a physician. For general stress support and wellness: 1 capsule daily. For cortisol management, performance, or higher-stress periods: 2 capsules daily (split morning and evening or both at once). For sleep support: 1 capsule 30-60 minutes before bedtime. Take consistently every day for best results — effects are cumulative. Vegetarian capsule. Made without gluten or lactose. No artificial ingredients.†

Why Buy at Get Yok'd

• Real-time inventory across all five Southern California stores
• Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
• Authorized retailer of NutraBio
• One of the best loyalty programs in the supplement industry — earn rewards on every purchase
• Owned and operated by fitness enthusiasts who actually use what we sell

Who Should Not Take NutraBio KSM-66 Ashwagandha

• Not for use by pregnant or nursing women
• Not for individuals with hyperthyroidism or active thyroid disorders without physician guidance
• Not for individuals taking thyroid medications without physician guidance — KSM-66 has documented effects on T3 and T4 levels that may alter medication requirements
• Not for individuals with autoimmune conditions (lupus, rheumatoid arthritis, multiple sclerosis) — ashwagandha may stimulate the immune system and potentially worsen these conditions
• Consult a physician before use if taking any prescription medications, especially immunosuppressants, sedatives, or thyroid medications
• Consult a physician before use if you have liver disease — rare cases of hepatotoxicity have been reported with high-dose ashwagandha use; NutraBio KSM-66 at standard doses is generally well-tolerated but individual sensitivity varies
• Discontinue 2 weeks before any surgical procedure — may enhance sedative effects of anesthesia
• Manufactured in a facility that processes milk, eggs, and fish
• Keep out of reach of children

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.