Hi-Tech Pharmaceuticals - Synadrene - 45 Capsules

Hi-Tech Pharmaceuticals Synadrene is the reverse-engineered successor to one of the most sought-after fat burners ever made — an 815mg proprietary weight loss blend combining Caffeine Anhydrous, Green Tea Extract, 2-Aminoisoheptane HCl (DMHA), Walnut Extract, Sulbutiamine, Sandalwood Extract, Yohimbine Extract, Alpha Lipoic Acid, and Poly-liodo-Thyronine alongside a B-vitamin complex (B3, B6, B12) and 175mcg Chromium. Hi-Tech describes the energy as clean, long-lasting, and smooth — strong enough to drive intense cardio and high-intensity training without the nervousness or distracting overstimulation of lower-quality stimulant products, and without a hard crash when it tapers. 45 capsules per bottle. Take 1 capsule three times daily. Do not exceed 4 capsules in any 24-hour period. Suitable for men and women. Cycle up to 8 weeks with a 2-4 week break. Not for tested athletes — contains DMHA and Yohimbine, both prohibited by WADA and NCAA. This product can raise blood pressure and interfere with other medications — consult a physician before use. California Prop 65 Warning applies.†

WARNING: Synadrene is a high-stimulant product containing DMHA (2-Aminoisoheptane HCl) and Yohimbine. This product can raise blood pressure and interfere with other drugs. Do not combine with any other stimulants, caffeine sources, or medications including MAOIs. Not for persons under 18. Consult a physician before use.

Supplement Facts — Hi-Tech Pharmaceuticals Synadrene (Per 1 Capsule / 45 Capsules)

Vitamins and Minerals

• Vitamin B3 (as Niacin) — 20mg
• Vitamin B6 (as Pyridoxine HCl) — 4.25mg
• Vitamin B12 (as Cyanocobalamin) — 100mcg
• Chromium — 175mcg

Synedrex Formulated Weight Loss Solution Blend — 815mg (Proprietary)

• Caffeine Anhydrous — primary CNS stimulant, thermogenic, and energy driver
• Green Tea Extract (Leaves) — EGCG-mediated thermogenesis and COMT inhibition for extended norepinephrine activity
• 2-Aminoisoheptane HCl (DMHA) — CNS stimulant with warm euphoric energy, bronchodilation, and dopamine/norepinephrine reuptake inhibition
• Walnut Extract (Bark) — Juglans Regia source of 2-aminoisoheptane alkaloids; additional stimulant activity
• Sulbutiamine — fat-soluble thiamine (B1) derivative with nootropic and anti-fatigue properties; crosses blood-brain barrier more readily than standard B1
• Sandalwood Extract — alpha-santalol; promotes calmness and focus to temper stimulant overstimulation
• Yohimbine Extract (Bark) — alpha-2 adrenergic receptor antagonist; fat mobilization and CNS stimulation
• Alpha Lipoic Acid (ALA) — universal antioxidant; insulin mimetic for glucose partitioning and nutrient disposition
• Poly-liodo-Thyronine — thyroid hormone support compound for metabolic rate regulation

• Other Ingredients: Dicalcium Phosphate, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1, FD&C Red #40, Gelatin
• 815mg proprietary blend per capsule — individual ingredient doses not disclosed
• 45 capsules per container — 15 days at full 3-capsule/day dose, or 45 days at 1 capsule/day tolerance assessment
• Take 1 capsule three times daily. Do not exceed 4 capsules in any 24-hour period.
• New users: start with 1 capsule daily for the first several days to assess tolerance
• Cycle up to 8 weeks maximum. Take a 2-4 week break before resuming.
• Do not combine with other stimulants, caffeine sources (coffee, tea, energy drinks), or medications
• Does not contain Synephrine or DMAA
• Not for tested athletes — DMHA and Yohimbine are prohibited by WADA and NCAA
• This product can raise blood pressure and interfere with other medications
• California Prop 65 Warning applies.

The Synadrene Origin Story — Why This Formula Exists

To understand Synadrene, you need to understand what came before it. Synedrex by Metabolic Nutrition was one of the most popular fat burners ever made — a DMAA-powered thermogenic that developed a devoted following for its potent, clean energy and significant fat loss results. When the FDA applied pressure on DMAA-containing products, Synedrex was reformulated with AMP Citrate (DMBA). The FDA then scrutinized AMP Citrate as well, creating a second disruption.†

Hi-Tech Pharmaceuticals stepped into this void. Their researchers reverse-engineered the Synedrex formula — not to produce a copy but to improve on it. The result is Synadrene: the same foundational weight loss formula philosophy, with DMHA (2-Aminoisoheptane) replacing DMAA as the primary high-stim compound. DMHA is a legal dietary supplement ingredient with similar CNS stimulant properties to DMAA — the same warm, focused, euphoric energy that made the original Synedrex popular, through a compound that is currently legal in all 50 US states. Hi-Tech's tagline captures the intent: "Why settle for New and Marginal when you can have New and Improved?"†

The Nine-Compound Blend — What Each Ingredient Does

Caffeine Anhydrous — The Energy Foundation

Caffeine Anhydrous is the primary fast-acting CNS stimulant in Synadrene — the adenosine antagonist that produces the immediate alertness, thermogenic caloric expenditure increase, and training intensity support that anchors the formula. Individual dose within the 815mg blend is not disclosed (proprietary blend), but the caffeine content drives the immediate energy onset that users feel within 20-30 minutes of the first capsule. Caffeine's phosphodiesterase inhibition raises intracellular cAMP, amplifying the lipolysis (fat cell breakdown) signal from beta-adrenergic activation — meaning caffeine both provides energy and directly promotes fat mobilization from adipose tissue.†

Green Tea Extract — Norepinephrine Protection and Thermogenesis

Green Tea Extract (standardized for EGCG catechins) extends and amplifies the effects of the catecholamines (norepinephrine, dopamine) that DMHA and caffeine release. EGCG inhibits catechol-O-methyltransferase (COMT) — the enzyme that degrades norepinephrine. By protecting norepinephrine from enzymatic breakdown, EGCG extends the duration of norepinephrine's thermogenic and fat-mobilizing signal. Green tea catechins also directly activate fat oxidation through PPARα activation — the gene expression mechanism that upregulates mitochondrial fat-burning enzymes. The thermogenic effect of Green Tea at meaningful doses is well-documented in multiple human clinical trials.†

2-Aminoisoheptane HCl (DMHA) — The Signature Stimulant

DMHA (2-Aminoisoheptane, also known as 2-amino-5-methylheptane or octodrine) is the compound that gives Synadrene its distinctive energy character. As an aliphatic amine structurally related to DMAA, DMHA produces CNS stimulation, bronchodilation, appetite suppression, and thermogenesis through adrenergic receptor activation and monoamine reuptake inhibition. The subjective experience — a warm, euphoric, motivated energy with pronounced focus and appetite suppression — is what recreates the Synedrex experience for users who remember it. DMHA's effects are smoother and slightly longer-lasting than DMAA's harder adrenergic profile, and it produces less acute cardiovascular stress than DMAA at equivalent subjective intensity. DMHA is currently legal in the United States as a dietary supplement ingredient. It is prohibited by WADA.†

Walnut Extract (Bark) — Additional DMHA Alkaloids

Walnut (Juglans Regia) bark extract is included as a secondary source of 2-aminoisoheptane alkaloids — the same compound class as DMHA. Hi-Tech uses both the synthetic HCl salt (2-Aminoisoheptane HCl) and the plant-derived Juglans Regia extract to provide DMHA through two distinct sources. The plant-derived DMHA from walnut extract may have a slightly different release kinetic and alkaloid profile than the pure synthetic form, contributing to the formula's sustained energy characteristic.†

Sulbutiamine — The Nootropic Fatigue Fighter

Sulbutiamine is a synthetic derivative of thiamine (Vitamin B1) in which two thiamine molecules are bound together with a sulfur group — a structural modification that makes the compound significantly more fat-soluble than standard thiamine and dramatically improves its ability to cross the blood-brain barrier. In the brain, Sulbutiamine is cleaved to active thiamine, which is essential for acetylcholine synthesis and the enzymatic reactions of aerobic energy metabolism. Sulbutiamine's primary effects are anti-fatigue and nootropic — it reduces central nervous system fatigue, improves memory formation, and produces a distinct mood-elevating effect that contributes to Synadrene's "smooth, clean energy" character. The Sulbutiamine in Synadrene helps prevent the mental fatigue that typically develops during prolonged caloric restriction, ensuring sustained cognitive drive through cutting phases.†

Sandalwood Extract — The Balance Compound

Sandalwood (Santalum album) extract contains alpha-santalol and beta-santalol — sesquiterpene compounds with documented anxiolytic, mood-elevating, and mildly sedative properties. In the context of a high-stimulant formula, Sandalwood Extract serves as the balancing compound — its alpha-santalol content activates the parasympathetic nervous system through olfactory and systemic pathways, reducing the anxious edge that high-dose stimulants produce in sensitive individuals. The inclusion of a calming botanical alongside potent stimulants is Hi-Tech's approach to the "smooth without nervousness" character they describe as central to Synadrene's experience. This is the ingredient that prevents the formula from feeling like a raw caffeine and DMHA dump — it produces focus and drive without the jittery, distracted overstimulation that poor formula design produces.†

Yohimbine Extract — Alpha-2 Fat Mobilization

Yohimbine (from Pausinystalia yohimbe bark) is an alpha-2 adrenergic receptor antagonist — it blocks the receptors in fat cells that inhibit lipolysis, removing the physiological brake on fat mobilization particularly in the stubborn subcutaneous fat depots where alpha-2 receptor density is highest. Yohimbine's fat-mobilizing effect is most pronounced in a fasted state, complementing Synadrene's use before cardio and training sessions. Yohimbine also produces CNS stimulant and mood-elevating effects that contribute to the formula's overall energy experience. Yohimbine is prohibited by WADA.†

Alpha Lipoic Acid — Glucose Partitioning and Antioxidant Support

Alpha Lipoic Acid (ALA) in Synadrene serves a specific metabolic function: it activates glucose transporters (GLUT4) in skeletal muscle through insulin-mimetic mechanisms, helping redirect glucose from blood into muscle cells for energy rather than fat cells for storage. This nutrient partitioning effect means the carbohydrates consumed during a cutting phase are more likely to replenish muscle glycogen and less likely to contribute to fat storage — supporting body composition during the caloric restriction period where Synadrene is typically used. ALA's universal antioxidant activity (both water-soluble and fat-soluble compartments) provides additional cellular protection during the elevated metabolic activity that the stimulant blend produces.†

Poly-liodo-Thyronine — Metabolic Rate Support

Poly-liodo-Thyronine is a thyroid hormone-supporting compound — a synthetic analog of triiodothyronine (T3) or a compound that supports endogenous thyroid hormone activity. Thyroid hormones are the primary regulators of basal metabolic rate — T3 and T4 govern the rate at which cells burn calories at rest. During caloric restriction, the body's thyroid hormone output naturally decreases as an adaptive mechanism to conserve energy — a process that progressively slows fat loss as a diet continues. Thyroid support compounds work to maintain thyroid hormone activity during this adaptation, preventing the metabolic slowdown that makes extended dieting progressively less effective. This is one of Synadrene's most distinctive and often overlooked ingredients — addressing the dietary adaptation problem that no amount of caffeine or DMHA alone can overcome.†

The B-Vitamin Complex — Supporting Energy Metabolism

The inclusion of B3 (Niacin, 20mg), B6 (Pyridoxine HCl, 4.25mg), B12 (Cyanocobalamin, 100mcg), and Chromium (175mcg) alongside the stimulant blend serves the metabolic infrastructure that the active compounds demand. B-vitamins are essential cofactors for the mitochondrial energy production pathways — niacin as NAD+/NADH, B6 as pyridoxal-5'-phosphate for amino acid metabolism and neurotransmitter synthesis, B12 for methylation and red blood cell production. The elevated metabolic rate from the stimulant blend increases the demand for these cofactors. Chromium at 175mcg complements Alpha Lipoic Acid's glucose partitioning effect, potentiating insulin receptor signaling for improved carbohydrate-to-muscle utilization.†

Synadrene vs. Lipodrene Elite — Two Different Approaches

Get Yok'd carries both Synadrene and Lipodrene Elite — both are Hi-Tech's high-stim fat burners with DMHA, and both represent the brand's answer to what the original DMAA supplements achieved. The key differences: Synadrene is capsule format with 9 active compounds in a single blend. Lipodrene Elite is tablet format with Hi-Tech's Thermo-Rx and Extend-Rx delivery systems, Erythroxylum Coca Extract (decocainized), and Senegalia Berlandieri PEA alkaloids (170mg PEA alkaloids) — a different and more complex stimulant architecture. Lipodrene Elite has the more aggressive catecholamine-releasing mechanism through the coca alkaloids. Synadrene has the Sulbutiamine nootropic and Sandalwood balance compounds that give it the smoother, less overwhelming energy character. For users who want maximum catecholaminergic stimulation: Lipodrene Elite. For users who want powerful but smoother energy with nootropic and thyroid support: Synadrene.†

Frequently Asked Questions

1. How does Synadrene compare to the original Synedrex?
   Hi-Tech's Synadrene was specifically reverse-engineered from the original Synedrex formula. The primary difference is the stimulant compound: DMHA (2-Aminoisoheptane) replaces DMAA (1,3-dimethylamylamine) — DMAA is no longer available in dietary supplements following FDA action. DMHA produces a similar warm, focused, euphoric energy to DMAA with a slightly smoother profile. Users familiar with the original Synedrex consistently describe Synadrene as the closest currently legal equivalent to the DMAA-era Synedrex experience.†
2. What is Sulbutiamine and why is it in a fat burner?
   Sulbutiamine is a fat-soluble B1 derivative that crosses the blood-brain barrier far more readily than standard thiamine. Its primary relevant effect in a fat burner context is anti-fatigue and nootropic — it reduces the mental fatigue that develops during caloric restriction and extended dieting, maintaining the cognitive drive and motivation that keep training intensity high even on a caloric deficit. It's the ingredient most responsible for Synadrene's reputation for smooth, sustained energy without the mental flatness that follows heavy stimulant use — Sulbutiamine actively supports the brain chemistry that maintains drive and focus alongside the catecholamine-based energy.†
3. How long should I use Synadrene before taking a break?
   Maximum 8 weeks of continuous use followed by a 2-4 week break. The cycle limit is related to both the thyroid hormone support component (which benefits from periodic breaks to maintain the receptor sensitivity of the thyroid pathway) and the standard tolerance management recommendation for DMHA and Yohimbine. Starting with 1 capsule daily for the first week to assess tolerance is strongly recommended before advancing to the full 3-capsule daily dose.†
4. Is Synadrene appropriate for tested athletes?
   No. Synadrene contains DMHA (2-Aminoisoheptane) and Yohimbine — both of which are prohibited by WADA and the NCAA. Athletes in any tested sport at any level must not use this product. The B-vitamins, ALA, Green Tea, Sulbutiamine, and Sandalwood components are permitted, but the presence of DMHA and Yohimbine makes the entire formula non-compliant for tested environments.†

How to Take Hi-Tech Pharmaceuticals Synadrene

New users: begin with 1 capsule daily in the morning to assess individual tolerance before advancing to the full dose. Full dose: take 1 capsule three times daily — morning, midday, and early afternoon. Do not exceed 4 capsules in any 24-hour period. Do not take within 6 hours of bedtime — DMHA's extended duration can persist significantly longer than caffeine alone and will disrupt sleep. Do not combine with coffee, tea, energy drinks, pre-workouts, or any other stimulant-containing products. Do not combine with Synephrine products — Hi-Tech specifically warns against this combination. Avoid other caffeine sources within 3 hours of any Synadrene dose. Cycle: maximum 8 weeks on, 2-4 weeks off before resuming. Can be stacked with non-stimulant fat loss aids (CLA, L-Carnitine). Suitable for men and women. Not for persons under 18. Not for pregnant or nursing women. This product can raise blood pressure and interfere with other medications — consult a physician before use. California Prop 65 Warning applies.†

Why Buy at Get Yok'd

• Real-time inventory across all five Southern California stores
• Available in Burbank, Glendale, Glendale Galleria, Pasadena, and North Hollywood
• Authorized Hi-Tech Pharmaceuticals retailer — carrying Synadrene alongside the full Hi-Tech fat burner lineup including Lipodrene Elite, Lipodrene Original, and Fastin
• Staff who can walk you through the Hi-Tech fat burner family and help you find the right formula for your tolerance and goals
• One of the best loyalty programs in the supplement industry — earn rewards on every purchase

Who Should Not Take Synadrene

• Not for persons under 18 years of age
• Not for pregnant or nursing women
• Not for tested athletes — contains DMHA (2-Aminoisoheptane) and Yohimbine, both prohibited by WADA and NCAA
• Not for individuals with cardiovascular conditions, high blood pressure, or heart arrhythmia — this product can raise blood pressure significantly
• Not for individuals with anxiety disorders — DMHA and Yohimbine can powerfully amplify anxiety in susceptible individuals
• Not for individuals with thyroid disorders without physician clearance — contains thyroid hormone-supporting Poly-liodo-Thyronine
• Not for individuals with liver, kidney, or psychiatric disorders without physician clearance
• Not for individuals with seizure disorders
• Not for individuals with enlarged prostate or glaucoma
• Do NOT combine with MAO inhibitors, antidepressants, Synephrine-containing products, or any other stimulant medications or supplements
• Do not combine with any caffeine sources — coffee, tea, soda, energy drinks, pre-workouts
• Do not exceed 4 capsules in any 24-hour period
• Do not use for longer than 8 weeks without a break
• Discontinue use 2 weeks before any scheduled surgery
• This product can raise blood pressure and interfere with other drugs — consult a physician before use
• California Prop 65 Warning applies.
• Keep out of reach of children.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.